Inflammatory Links Between High Fat Diets and Diseases

被引：355
作者：
Duan, Yehui [1 ]
Zeng, Liming [2 ]
Zheng, Changbing [3 ]
Song, Bo [3 ]
Li, Fengna [1 ]
Kong, Xiangfeng [1 ]
Xu, Kang [1 ]
机构：
[1] Chinese Acad Sci, Hunan Prov Key Lab Anim Nutr Physiol & Metab Proc, Key Lab Agroecol Proc Subtrop Reg,Sci Observing &, Inst Subtrop Agr,Hunan Prov Engn Res Ctr Hlth Liv, Changsha, Hunan, Peoples R China
[2] Jiangxi Agr Univ, Sci Coll, Nanchang, Jiangxi, Peoples R China
[3] South China Agr Univ, Guangdong Prov Key Lab Anim Nutr Regulat, Guangzhou, Guangdong, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷
基金：
中国国家自然科学基金;
关键词：
high-fat diets; inflammation; disease; mechanisms; drug therapy; INDUCED INSULIN-RESISTANCE; ADIPOSE-TISSUE INFLAMMATION; ACTIVATED RECEPTOR-DELTA; MESENCHYMAL STEM-CELLS; INDUCED-OBESITY; GUT MICROBIOTA; BOWEL-DISEASE; BONE MASS; SKELETAL-MUSCLE; MOUSE MODEL;
D O I：
10.3389/fimmu.2018.02649
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In recent years, chronic overnutrition, such as consumption of a high-fat diet (HFD), has been increasingly viewed as a significant modifiable risk factor for diseases such as diabetes and certain types of cancer. However, the mechanisms by which HFDs exert adverse effects on human health remains poorly understood. Here, this paper will review the recent scientific literature about HFD-induced inflammation and subsequent development of diseases and cancer, with an emphasis on mechanisms involved. Given the expanding global epidemic of excessive HFD intake, understanding the impacts of a HFD on these medical conditions, gaining great insights into possible underlying mechanisms, and developing effective therapeutic strategies are of great importance.
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页数：10
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