Curcumin-PVP Loaded Electrospun Membranes with Conferred Antibacterial and Antitumoral Activities

被引：16
作者：
Yakub, Gyuldzhan [1 ]
Toncheva, Antoniya [1 ]
Kussovski, Veselin [2 ]
Toshkova, Reneta [3 ]
Georgieva, Ani [3 ]
Nikolova, Elena [3 ]
Manolova, Nevena [1 ]
Rashkov, Iliya [1 ]
机构：
[1] Bulgarian Acad Sci, Lab Bioact Polymers, Inst Polymers, BU-1113 Sofia, Bulgaria
[2] Bulgarian Acad Sci, Inst Microbiol, BU-1113 Sofia, Bulgaria
[3] Bulgarian Acad Sci, Inst Expt Morphol Pathol & Anthropol Museum, BU-1113 Sofia, Bulgaria
来源：
FIBERS AND POLYMERS | 2020年 / 21卷 / 01期
关键词：
Nanomaterials; Electrospinning; Polylactic acid; Curcumin; Antibacterial and antitumoral activity; FIBROUS MATERIALS; NANOFIBERS; SOLUBILITY; RELEASE; FIBERS; POLYLACTIDE; FABRICATION; COMPLEX; SYSTEM;
D O I：
10.1007/s12221-020-9473-z
中图分类号：
TB3 [工程材料学]; TS1 [纺织工业、染整工业];
学科分类号：
0805 ; 080502 ; 0821 ;
摘要：
Electrospun membranes containing curcumin were prepared from poly(L-co-D,L-lactic) acid and polyvinylpyrrolidone. The effect of curcumin concentration on the solution viscosity and the morphology of fiber was studied. Curcumin solubility in aqueous solutions was enhanced by the formation of curcumin/polyvinylpyrrolidone water-soluble complex. Curcumin physico-chemical and therapeutic properties within the membranes were preserved upon UV-Vis light irradiation, as a part of the membranes sterilization. The biomaterials showed antibacterial activity against pathogenic microorganisms such as Staphylococcus aureus and Candida albicans. In-vitro experiments against HeLa and Graffi tumor cells and white blood cells (peritoneal macrophages and spleen lymphocytes) revealed potential biomedical application of the membranes.
引用
收藏
页码：55 / 65
页数：11
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