Pathology of radiation and anthracycline cardiotoxicity

被引：80

作者：

Berry, GJ

Jorden, M

机构：

[1] Stanford Univ, Med Ctr, Lab Surg Pathol, Stanford, CA 94305 USA

[2] Stanford Univ, Med Ctr, Div Cardiac Pathol, Dept Pathol, Stanford, CA 94305 USA

来源：

PEDIATRIC BLOOD & CANCER | 2005年 / 44卷 / 07期

关键词：

anthracycline cardiac pathology; coronary artery disease; radiation cardiac pathology; radiation valvular disease;

D O I：

10.1002/pbc.20346

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Radiation-induced heart disease (RIHD) and anthracycline cardiotoxicity are two patterns of cardiac dysfunction caused by therapeutic interventions to treat malignancies. They occur in both the pediatric and adult populations and there is evidence to suggest that pediatric patients are at greater risk. This is due in part to the longer survival rates but also reflects increased susceptibility to the attendant complications caused by both therapies. Radiation can cause injury to all the components of the heart, including the vasculature, while anthracycline toxicity is generally limited to the myocardium. (c) 2005 Wiley-Liss, Inc.

引用

页码：630 / 637

页数：8

共 48 条

[1] Radiation-associated cardiovascular disease [J].