A Bioelectronic Platform Using a Graphene-Lipid Bilayer Interface

被引：118

作者：

Ang, Priscilla Kailian ^{[1
,2
]}

Jaiswal, Manu ^{[1
]}

Lim, Candy Haley Yi Xuan ^{[1
,2
]}

Wang, Yu ^{[1
]}

Sankaran, Jagadish ^{[1
]}

Li, Ang ^{[3
]}

Lim, Chwee Teck ^{[4
,5
,6
]}

Wohland, Thorsten ^{[1
]}

Oezyilmaz, Barbaros ^{[7
]}

Loh, Kian Ping ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[2] NUS Grad Sch Integrat Sci & Engn, Singapore 117597, Singapore

[3] Singapore MIT Alliance Res & Technol SMART, Singapore 117456, Singapore

[4] Natl Univ Singapore, Dept Mech Engn, Singapore 117576, Singapore

[5] Natl Univ Singapore, Div Bioengn, Singapore 117576, Singapore

[6] Natl Univ Singapore, Mechanobiol Inst, Singapore 117411, Singapore

[7] Natl Univ Singapore, Dept Phys, Singapore 117542, Singapore

来源：

ACS NANO | 2010年 / 4卷 / 12期

关键词：

graphene; lipid bilayer; membrane disruption; bioelectronic interface; biomolecular doping; ionic screening; ELECTRIC CHARGE; MAGAININ; 2; MEMBRANES; PEPTIDE; SPECTROSCOPY; ORGANIZATION; TRANSISTORS; MICROSCOPY; SCATTERING; PROTEGRIN;

D O I：

10.1021/nn1022582

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The electronic properties of graphene can be modulated by charged lipid bilayer adsorbing on the surface. Biorecognition events which lead to changes in membrane integrity can be monitored electrically using an electrolyte-gated biomimetic membrane-graphene transistor. Here, we demonstrate that the bactericidal activity of antimicrobial peptides can be sensed electrically by graphene based on a complex interplay of biomolecular doping and ionic screening effect.

引用

页码：7387 / 7394

页数：8

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