Quality assessment of a formulated Chinese herbal decoction, Kaixinsan, by using rapid resolution liquid chromatography coupled with mass spectrometry: A chemical evaluation of different historical formulae

被引：34
作者：
Zhu, Kevin Y. [1 ,2 ]
Fu, Q. [1 ,2 ]
Xie, Heidi Q. [1 ,2 ]
Xu, Sherry L. [1 ,2 ]
Cheung, Anna W. H. [1 ,2 ]
Zheng, Ken Y. Z. [1 ,2 ]
Luk, Wilson K. W. [1 ,2 ]
Choi, Roy C. Y. [1 ,2 ]
Lau, David T. W. [1 ,2 ]
Dong, Tina T. X. [1 ,2 ]
Jiang, Zhi Y. [3 ]
Chen, Ji J. [3 ]
Tsim, Karl W. K. [1 ,2 ]
机构：
[1] Hong Kong Univ Sci & Technol, Div Life Sci, Sect Marine Ecol & Biotechnol, Hong Kong, Hong Kong, Peoples R China
[2] Hong Kong Univ Sci & Technol, Ctr Chinese Med, Hong Kong, Hong Kong, Peoples R China
[3] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Yunnan, Peoples R China
来源：
JOURNAL OF SEPARATION SCIENCE | 2010年 / 33卷 / 23-24期
关键词：
Chemical assessment; Depression; Herbal mixture; LC-MS; TCM; RADIX ASTRAGALI; PC12; CELLS; PERFORMANCE; DX-9386; PRESCRIPTION; PRINCIPLES; SINENSIS; EXTRACT; GINSENG; STRESS;
D O I：
10.1002/jssc.201000498
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Kaixinsan is an ancient Chinese herbal decoction mainly prescribed for patients suffering from mental depression. This decoction was created by Sun Si-miao of Tang Dynasty (A.D. 600) in ancient China, and was composed of four herbs: Radix and Rhizome Ginseng, Radix Polygalae, Rhizoma Acori Tatarinowii and Poria. Historically, this decoction has three different formulations, each recorded at a different point in time. In this study, the chemical compositions of all three Kaixinsan formulae were analyzed. By using rapid resolution LC coupled with a diode-array detector and an ESI triple quadrupole tandem MS (QQQ-MS/MS), the Radix and Rhizome Ginseng-derived ginsenosides including Rb-1, Rd, Re, Rg(1), the Radix Polygalae-derived 3,6'-disinapoyl sucrose, the Rhizoma Acori Tatarinowii-derived alpha-and beta-asarone and the Poria-derived pachymic acid were compared among the three different formulations. The results showed variations in the solubility of different chemicals between one formula and the others. This systematic method developed could be used for the quality assessment of this herbal decoction.
引用
收藏
页码：3666 / 3674
页数：9
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