Usefulness of S100P in diagnosis of adenocarcinoma of pancreas on fine-needle aspiration biopsy specimens

被引：44
作者：
Deng, Hongbing [1 ]
Shi, Jianhui [1 ]
Wilkerson, Myra [1 ]
Meschter, Steven [1 ]
Dupree, William [1 ]
Lin, Fan [1 ]
机构：
[1] Geisinger Med Ctr, Dept Lab Med, Danville, PA 17822 USA
来源：
AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2008年 / 129卷 / 01期
关键词：
S100P; pancreas; adenocarcinoma; fine-needle aspiration biopsy;
D O I：
10.1309/5D76NDE81LE8G545
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Even though the cytologic criteria for pancreatic ductal adenocarcinoma (PDA) on fine-needle aspiration biopsy (FNAB) specimens have been well defined, a diagnostic challenge is still present. We immunohistochemically evaluated the diagnostic value of S100P on cell-block and/or smear preparations in 58 cases of FNAB specimens of the pancreas. The 58 cases were divided into 4 groups: 1, 32 cases of PDA; 2, 6 cases with an atypical or "suspicious" diagnosis; 3, 14 cases of benign or reactive ductal epithelium; and 4, 6 cases of endocrine tumor Positive immunoreactivity for S100P was observed in all cases in groups I and 2, whereas only I of 14 cases in group 3 was positive for S100P All cases in group 4 were negative for S100P S100P is a sensitive and specific marker for the detection of PDA on FNAB specimens on cell-block and smear preparations.
引用
收藏
页码：81 / 88
页数：8
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