Alterations of Serum Uric Acid Level and Gut Microbiota After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy in a Hyperuricemic Rat Model

被引：19
作者：
Lu, Cunlong [1 ,2 ]
Li, Yu [2 ]
Li, Long [3 ]
Kong, Ying [4 ]
Shi, Tuo [5 ]
Xiao, Hai [1 ]
Cao, Shougen [2 ]
Zhu, Houxin [2 ]
Li, Zequn [2 ]
Zhou, Yanbing [2 ]
机构：
[1] Peoples Hosp Ju Xian, Dept Gen Surg, Rizhao 276500, Shandong, Peoples R China
[2] Qingdao Univ, Dept Gastrointestinal Surg, Affiliated Hosp, Qingdao 266000, Shandong, Peoples R China
[3] Weihai Cent Hosp, Dept Gastrointestinal Surg, Weihai 264400, Shandong, Peoples R China
[4] Jining 1 Peoples Hosp, Dept Gastrointestinal Surg, 6 Jiankang Rd, Jining City, Shandong, Peoples R China
[5] Baoji Cent Hosp, Dept Cardiovasc Surg, Baoji, Shanxi, Peoples R China
来源：
OBESITY SURGERY | 2020年 / 30卷 / 05期
关键词：
Roux-en-Y gastric bypass; Sleeve gastrectomy; Serum uric acid; Gut microbiota; Lipopolysaccharides; Xanthine oxidase; XANTHINE-OXIDASE ACTIVITY; LIPOPOLYSACCHARIDE-BINDING PROTEIN; WEIGHT-LOSS; OXIDOREDUCTASE GENE; INSULIN-RESISTANCE; BARIATRIC SURGERY; MORBID-OBESITY; EXPRESSION; REDUCTION; DEHYDROGENASE;
D O I：
10.1007/s11695-019-04328-y
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Background The objective of this study was to observe alterations of serum uric acid (SUA) level and gut microbiota after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) surgery in a hyperuricemic rat model. Method We performed Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) surgery in a hyperuricemic rat model. Serum uric acid (UA), xanthine oxidase (XO) activity, IL-6, TNF-alpha and lipopolysaccharide (LPS) level changes, and 16S rDNA of gut microbiota were analyzed. Results After the surgery, the RYGB and SG procedures significantly reduced body weight, serum UA, IL-6, TNF-alpha and LPS levels, and XO activity. In addition, the RYGB and SG procedures altered the diversity and taxonomic composition of the gut microbiota. Compared with Sham group, RYGB and SG procedures were enriched in the abundance of phylum Verrucomicrobia and species Akkermansia muciniphila, while the species Escherichia coli was reduced. Discussion We here concluded that bariatric surgery-induced weight loss and resolution of inflammatory remarkers as well as changes of gut microbiota may be responsible for the reduced XO activity and SUA level. To have a better understanding of the underlying mechanism of UA metabolism following bariatric surgery, further research is needed.
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收藏
页码：1799 / 1807
页数：9
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