Ru(II)-catalyzed ring closing metathesis in stereoselective syntheses of constrained homoserine analogues

被引：32

作者：

Hammer, K ^{[1
]}

Romming, C ^{[1
]}

Undheim, K ^{[1
]}

机构：

[1] Univ Oslo, Dept Chem, N-0315 Oslo, Norway

来源：

TETRAHEDRON | 1998年 / 54卷 / 36期

关键词：

D O I：

10.1016/S0040-4020(98)00626-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereoselective syntheses of cyclic alpha-amipo-gamma-hydroxycyclohexene- and cycloheptene-alpha-carboxylic acids are described. RCM cyclization reactions were effected by Ru(II)-catalysis on sterically homogenous hydroxylated dienes. The diene substrates were available by stepwise, stereoselective alkylations of (R)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine with bromoalkenes, ethylene oxide and subsequent transformations. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：10837 / 10850

页数：14

共 22 条

[1]

*AN XRAY INSTR INC, SMART SAINT AR DET C

[2]

Armstrong SK, 1998, J CHEM SOC PERK T 1, P371

[3]

Avenoza A, 1997, SYNTHESIS-STUTTGART, P165

[4] Synthesis of a new enantiomerically pure constrained homoserine. [J].