The efficiency of antiviral therapy in patients with chronic hepatitis C infected with hepatitis C virus recombinants

被引：1
作者：
Yushchuk, N. D. [1 ]
Znoyko, O. O. [1 ]
Dudina, K. R. [1 ]
Kozina, A. N. [1 ]
Kalinina, O. V. [2 ]
机构：
[1] AI Evdokimov Moscow State Univ Med & Dent, Minist Hlth Russia, Moscow, Russia
[2] Pasteur St Petersburg Res Inst Epidemiol & Microb, St Petersburg, Russia
来源：
TERAPEVTICHESKII ARKHIV | 2016年 / 88卷 / 06期
关键词：
hepatitis C virus recombinants; RF2k/1b; chronic hepatitis C; antiviral therapy; NS5B sequencing; NATURAL INTERGENOTYPIC RECOMBINANT; ALPHA-2A PLUS RIBAVIRIN; PEGINTERFERON ALPHA-2B; GENOTYPE; CLASSIFICATION; ORGANIZATION; INTERFERON; SUBTYPE; STRAINS; REGION;
D O I：
10.17116/terarkh2016886101-105
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The review gives the data available in the literature on the efficiency of treatment in patients with chronic hepatitis C infected with hepatitis C virus (HCV) recombinants, by applying various antiviral therapy regimens. The low efficiency of treatment with pegylated interferons (PEG IFN) + ribavirin (RIB) and sofosburin (SOF) + RIB in this patient group (a sustained virologic response was achieved in 22 and 30.7%, respectively) compared with the efficiency of treatment (87-97 and 83-97%, respectively) in patients infected with HCV genotype 2 does not allow the 2015 EASL HCV genotype 2 treatment regimens to be used in such patients. In this connection, subtyping genotype 2 isolates by NS5B sequencing should be introduced into clinical laboratory practice to successfully detect recombinant HCVs and to enhance the efficiency of antiviral therapy.
引用
收藏
页码：101 / 105
页数：5
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