Recent Advances in Molecular Imaging with Gold Nanoparticles

被引：150

作者：

Bouche, Mathilde ^{[1
]}

Hsu, Jessica C. ^{[1
,2
]}

Dong, Yuxi C. ^{[1
,2
]}

Kim, Johoon ^{[1
,2
]}

Taing, Kimberly ^{[1
]}

Cormode, David P. ^{[1
,2
]}

机构：

[1] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

来源：

BIOCONJUGATE CHEMISTRY | 2020年 / 31卷 / 02期

关键词：

STEM-CELL TRACKING; IN-VIVO; COMPUTED-TOMOGRAPHY; CONTRAST AGENTS; INTRACELLULAR PH; POLYMERIC NANOPARTICLES; SURFACE FUNCTIONALITY; PHOTOTHERMAL THERAPY; SHELL NANOPARTICLES; POLYETHYLENE-GLYCOL;

D O I：

10.1021/acs.bioconjchem.9b00669

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Gold nanoparticles (AuNP) have been extensively developed as contrast agents, theranostic platforms, and probes for molecular imaging. This popularity has yielded a large number of AuNP designs that vary in size, shape, surface functionalization, and assembly, to match very closely the requirements for various imaging applications. Hence, AuNP based probes for molecular imaging allow the use of computed tomography (CT), fluorescence, and other forms of optical imaging, photoacoustic imaging (PAI), and magnetic resonance imaging (MRI), and other newer techniques. The unique physicochemical properties, biocompatibility, and highly developed chemistry of AuNP have facilitated breakthroughs in molecular imaging that allow the detection and imaging of physiological processes with high sensitivity and spatial resolution. In this Review, we summarize the recent advances in molecular imaging achieved using novel AuNP structures, cell tracking using AuNP, targeted AuNP for cancer imaging, and activatable AuNP probes. Finally, the perspectives and current limitations for the clinical translation of AuNP based probes are discussed.

引用

页码：303 / 314

页数：12