Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein

被引:475
作者
Xia, Shuai [1 ]
Zhu, Yun [2 ]
Liu, Meiqin [3 ]
Lan, Qiaoshuai [1 ]
Xu, Wei [1 ]
Wu, Yanling [1 ]
Ying, Tianlei [1 ]
Liu, Shuwen [4 ]
Shi, Zhengli [3 ]
Jiang, Shibo [1 ,5 ]
Lu, Lu [1 ]
机构
[1] Fudan Univ, Sch Basic Med Sci, Fudan Jinbo Joint Res Ctr, Key Lab Med Mol Virol MOE NHC CAMS, Shanghai, Peoples R China
[2] Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing, Peoples R China
[3] Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Peoples R China
[4] Southern Med Univ, Guangzhou Key Lab Drug Res Emerging Virus Prevent, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou, Peoples R China
[5] New York Blood Ctr, Lindsley F Kimball Res Inst, New York, NY 10021 USA
关键词
CORONAVIRUS;
D O I
10.1038/s41423-020-0374-2
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:765 / 767
页数:3
相关论文
共 8 条
[1]   Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [J].
Huang, Chaolin ;
Wang, Yeming ;
Li, Xingwang ;
Ren, Lili ;
Zhao, Jianping ;
Hu, Yi ;
Zhang, Li ;
Fan, Guohui ;
Xu, Jiuyang ;
Gu, Xiaoying ;
Cheng, Zhenshun ;
Yu, Ting ;
Xia, Jiaan ;
Wei, Yuan ;
Wu, Wenjuan ;
Xie, Xuelei ;
Yin, Wen ;
Li, Hui ;
Liu, Min ;
Xiao, Yan ;
Gao, Hong ;
Guo, Li ;
Xie, Jungang ;
Wang, Guangfa ;
Jiang, Rongmeng ;
Gao, Zhancheng ;
Jin, Qi ;
Wang, Jianwei ;
Cao, Bin .
LANCET, 2020, 395 (10223) :497-506
[2]   An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies [J].
Jiang, Shibo ;
Du, Lanying ;
Shi, Zhengli .
EMERGING MICROBES & INFECTIONS, 2020, 9 (01) :275-277
[3]   Structure of SARS coronavirus spike receptor-binding domain complexed with receptor [J].
Li, F ;
Li, WH ;
Farzan, M ;
Harrison, SC .
SCIENCE, 2005, 309 (5742) :1864-1868
[4]   Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors [J].
Liu, SW ;
Xiao, GF ;
Chen, YB ;
He, YX ;
Niu, JK ;
Escalante, CR ;
Xiong, HB ;
Farmar, J ;
Debnath, AK ;
Tien, P ;
Jiang, SB .
LANCET, 2004, 363 (9413) :938-947
[5]   Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor [J].
Lu, Lu ;
Liu, Qi ;
Zhu, Yun ;
Chan, Kwok-Hung ;
Qin, Lili ;
Li, Yuan ;
Wang, Qian ;
Chan, Jasper Fuk-Woo ;
Du, Lanying ;
Yu, Fei ;
Ma, Cuiqing ;
Ye, Sheng ;
Yuen, Kwok-Yung ;
Zhang, Rongguang ;
Jiang, Shibo .
NATURE COMMUNICATIONS, 2014, 5
[6]  
Wang Xian-Guang, 2020, NATURE, V579, P270, DOI DOI 10.1038/s41586-020-2012-7
[7]   A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike [J].
Xia, Shuai ;
Yan, Lei ;
Xu, Wei ;
Agrawal, Anurodh Shankar ;
Algaissi, Abdullah ;
Tseng, Chien-Te K. ;
Wang, Qian ;
Du, Lanying ;
Tan, Wenjie ;
Wilson, Ian A. ;
Jiang, Shibo ;
Yang, Bei ;
Lu, Lu .
SCIENCE ADVANCES, 2019, 5 (04)
[8]   Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains [J].
Yuan, Yuan ;
Cao, Duanfang ;
Zhang, Yanfang ;
Ma, Jun ;
Qi, Jianxun ;
Wang, Qihui ;
Lu, Guangwen ;
Wu, Ying ;
Yan, Jinghua ;
Shi, Yi ;
Zhang, Xinzheng ;
Gao, George F. .
NATURE COMMUNICATIONS, 2017, 8