Tranexamic acid reduces hidden blood loss in the treatment of intertrochanteric fractures with PFNA: a single-center randomized controlled trial

被引：78

作者：

Lei, Jinlai ^{[1
]}

Zhang, Binfei ^{[1
]}

Cong, Yuxuan ^{[1
]}

Zhuang, Yan ^{[1
]}

Wei, Xing ^{[1
]}

Fu, Yahui ^{[1
]}

Wei, Wei ^{[1
]}

Wang, Pengfei ^{[1
]}

Wen, Shiming ^{[1
]}

Huang, Hai ^{[1
]}

Wang, Hu ^{[1
]}

Han, Shuang ^{[1
]}

Liu, Shuguang ^{[1
]}

Zhang, Kun ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Dept Orthopaed Trauma, Xian Honghui Hosp, Hlth Sci Ctr, 555 Youyi East Rd, Xian, Shaanxi, Peoples R China

来源：

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH | 2017年 / 12卷

关键词：

Tranexamic acid; Hidden blood loss; Intertrochanteric femora; Fracture; PFNA; Randomized controlled trial; TOTAL KNEE ARTHROPLASTY; TRANSFUSION REQUIREMENTS; HIP FRACTURE; PLATE;

D O I：

10.1186/s13018-017-0625-9

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Background: Hidden blood loss is a major concern for patients undergoing hip surgery for intertrochanteric fracture. The objective of this study was to investigate whether tranexamic acid (TXA) could reduce postoperative hidden blood loss in patients undergoing hip surgery for intertrochanteric fracture. Methods: A total of 77 patients with intertrochanteric fracture were enrolled in this randomized controlled study. Patients received either 200 mL (1 g) of TXA (n = 37) or normal-saline (NS) (n = 40) i.v. before hip surgery using proximal femoral nail anti-rotation (PFNA). Hemoglobin and hematocrit levels were measured preoperatively and postoperatively at day 1 and 3. Visible and hidden blood loss volumes were calculated at postoperative day 3. Results: On postoperative day 3, the transfusion rate was significantly lower in the TXA group compared to the NS group, although mean hemoglobin and hematocrit levels were not significantly different between the two groups. However, the estimated hidden blood loss volume (210.09 +/- 202.14 mL vs. 359.35 +/- 290.12 mL; P < 0.05) and total blood loss volume (279.35 +/- 209.11 mL vs. 417.89 +/- 289.56 mL; P < 0.05) were significantly less in the TXA group compared to the NS group, respectively. Conclusion: TXA significantly reduced postoperative hidden blood loss in patients with intertrochanteric fracture who underwent PFNA.

引用

页数：6

共 36 条

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[2]

[Anonymous], BMC MUSCULOSKEL DIS

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