The relationship of DNA repair gene XPD, XRCC1, OGG1, APE1, and WRN polymorphism with the risk of age-related cataract in Hani people from Mojiang region in Yunnan

Age-related cataract (ARC) is the leading cause of blindness in the elderly. This study investigated DNA repair genes, XPD, XRCC1, OGG1, APE1, and WRN single nucleotide polymorphisms (SNPs), to clarify their relationship with ARC in Hani patients from Mojiang region in Yunnan. Polymerase chain reaction-ligase detection reaction (PCR-LDR) was used to perform genotype analysis in ARC patients and healthy control. The genotype frequency distribution of XPD, XRCC1, OGG1, APE1, and WRN SNP in Hani accorded with Hardy-Weinberg equilibrium principle. OGG1 genotype analysis: the frequency of allele G was significantly higher than the control (P = 0.008; OR: 1.468; 95% CI: 1.106-1.949); the risk of allele G was 1.468 times of allele A; CC genotype may be associated with ARC (OR: 1.716; 95% CI: 1.460-2.018); the risk of this genotype was 1.716 times of CG and GG genotypes. GG genotype may have protective effect on ARC (OR: 0.684; 95% CI: 0.568-0.823). XRCC1 genotype analysis: AG genotype may be associated with ARC (OR: 1.464; 95% CI: 1.108-1.934); AG genotype frequency was higher than control (P = 0.007); the risk of this genotype was 1.464 times of GG and AA genotypes; Alleles A frequency was significantly higher than the control (P = 0.010; OR: 1.329; 95% CI: 1.131-1.561); Allele A risk was 1.329 times of allele G. XPD, APE1, and WRN genotypes showed no relationship with ARC risk. OGG1 and XRCC1 gene polymorphisms were associated with ARC risk in Hani from Mojiang region in Yunnan.