Virtual reality cognitive-behavioural therapy versus cognitive-behavioural therapy for paranoid delusions: a study protocol for a single-blind multi-Centre randomised controlled superiority trial

被引：4

作者：

Berkhof, M. ^{[1
]}

van der Stouwe, E. C. D. ^{[1
]}

Lestestuiver, B. ^{[1
]}

Van't Hag, E. ^{[1
]}

van Grunsven, R. ^{[2
]}

de Jager, J. ^{[3
]}

Kooijmans, E. ^{[4
]}

Zandee, C. E. R. ^{[5
]}

Staring, A. B. P. ^{[6
]}

Pot-Kolder, R. M. C. A. ^{[7
]}

Vos, M. ^{[1
]}

Veling, W. ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands

[2] Parnassia Psychiat Inst, The Hague, Netherlands

[3] Mental Hlth Serv Org GGZ Noord Holland Noord, Heiloo, Heerhugowaard, Netherlands

[4] Pro Persona, Arnhem, Netherlands

[5] GGZ Delfland, Outpatient Treatment Ctr, Flexible Assert Community Treatment Team, Delft, Netherlands

[6] Altrecht Psychiat Inst, First Episode & Early Detect & Intervent Serv, Utrecht, Netherlands

[7] Vrije Univ Amsterdam, Dept Clin Psychol, Amsterdam, Netherlands

来源：

BMC PSYCHIATRY | 2021年 / 21卷 / 01期

关键词：

Psychotic disorder; Paranoia; Delusions; Social anxiety; Virtual reality; Cognitive Behavioural therapy; Social functioning; Cost-effectivity; PSYCHOMETRIC PROPERTIES; PERSECUTORY DELUSIONS; PSYCHOSIS; SCHIZOPHRENIA; SCALE; EXPERIENCE; INTERVENTIONS; INDIVIDUALS; METHODOLOGY; DISORDERS;

D O I：

10.1186/s12888-021-03473-y

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background Seventy per cent of patients with psychotic disorders has paranoid delusions. Paranoid delusions are associated with significant distress, hospital admission and social isolation. Cognitive-behavioural therapy for psychosis (CBTp) is the primary psychological treatment, but the median effect size is only small to medium. Virtual reality (VR) has a great potential to improve the effectiveness of CBTp. In a previous study, we found that VR based CBT (VRcbt) for paranoid delusions is superior to waiting list. As a next step, a direct comparison with CBTp is needed. The present study aims to investigate whether VRcbt is more effective and cost-effective than regular CBTp in treating paranoid delusions and improving daily life social functioning of patients with psychotic disorders. Methods A total of 106 patients with DSM-5 diagnosis of psychotic disorder and at least moderate level of paranoid ideations will be recruited for this multicentre randomized controlled trial (RCT). Patients will be randomized to either VRcbt or standard CBTp for paranoid delusions. VRcbt consists of maximum 16 sessions in virtual social situations that trigger paranoid ideations and distress, delivered in an 8-12 week time frame. Standard CBTp also consists of maximum 16 sessions including exposure and behavioural experiments, delivered in an 8-12 week time frame. The two groups will be compared at baseline, post-treatment and six months follow-up. Primary outcome is the level of paranoid ideations in daily life social situations, measured with ecological momentary assessments (EMA) at semi-random moments ten times a day during seven days, before and after treatment. Every session, participants and therapists will rate the level of paranoid ideation and global clinical impression. Discussion Comparison of VRcbt and CBTp will provide information about the relative (cost-) effectiveness of VRcbt for this population. VRcbt may become a preferred psychological treatment for paranoid delusions and social anxiety in patients with psychotic disorder.

引用

页数：10

共 47 条

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