Overcoming resistance to anti-CD19 CAR T-cell therapy in B-cell malignancies

被引：5

作者：

Yang, Xingcheng ^{[1
,2
]}

Wei, Jia ^{[1
,2
,3
]}

Zhou, Jianfeng ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Hematol, Tongji Med Coll, 1095 Jiefang Ave, Wuhan 430030, Hubei, Peoples R China

[2] Immunotherapy Res Ctr Hematol Dis Hubei Prov, Wuhan, Hubei, Peoples R China

[3] Huazhong Univ Sci & Technol, Dept Hematol, Shanxi Bethune Hosp,Tongji Med Coll, Shanxi Acad Med Sci,Shanxi Med Univ,Shanxi Tongji, Taiyuan, Peoples R China

来源：

HEMATOLOGICAL ONCOLOGY | 2022年 / 40卷 / 05期

基金：

中国国家自然科学基金;

关键词：

antigen escape; B-cell malignancy; CD19; chimeric antigen receptor; overcoming strategy; resistance; T cell exhaustion; CHIMERIC-ANTIGEN-RECEPTOR; MYELOID CELLS; PERIPHERAL-BLOOD; LINEAGE SWITCH; TUMOR-IMMUNITY; LEUKEMIA; LYMPHOMA; EFFICACY; ESCAPE; EXPRESSION;

D O I：

10.1002/hon.3036

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy has rapidly changed current treatment pattern, providing a better option for individuals with primary refractory or relapsed B-cell non-Hodgkin lymphoma (r/r B-NHL) and B-cell acute lymphoblastic leukemia (r/r B-ALL). However, despite the outstanding efficacy, a high relapse rate is still found in some B-cell malignancies after anti-CD19 CAR T-cell therapy, which emerges as a main barrier for improving the overall response and long-term outcomes. Understanding the resistance mechanism is crucial to improve current CAR T products, better incorporate them into the current therapy system and develop novel CAR approaches. Herein, we discuss the latest advances in understanding the mechanisms limiting efficacy of CAR T-cell therapy, resulting in CD19 negative (CD19(-)) and CD19 positive (CD19(+)) relapses. We also provide a whole scenario of current potential strategies to overcome these barriers.

引用

页码：821 / 834

页数：14

共 137 条

[41] Combinational Targeting Offsets Antigen Escape and Enhances Effector Functions of Adoptively Transferred T Cells in Glioblastoma [J].

Hegde, Meenakshi ;

Corder, Amanda ;

Chow, Kevin K. H. ;

Mukherjee, Malini ;

Ashoori, Aidin ;

Kew, Yvonne ;

Zhang, Yi Jonathan ;

Baskin, David S. ;

Merchant, Fatima A. ;

Brawley, Vita S. ;

Byrd, Tiara T. ;

Krebs, Simone ;

Wu, Meng Fen ;

Liu, Hao ;

Heslop, Helen E. ;

Gottachalk, Stephen ;

Yvon, Eric ;

Ahmed, Nabil .

MOLECULAR THERAPY, 2013, 21 (11) :2087-2101

[42] Tumor Burden Measured by 18F-FDG PET/CT in Predicting Efficacy and Adverse Effects of Chimeric Antigen Receptor T-Cell Therapy in Non-Hodgkin Lymphoma [J].

Hong, Ruimin ;

Tan Su Yin, Elaine ;

Wang, Linqin ;

Zhao, Xin ;

Zhou, Linghui ;

Wang, Guangfa ;

Zhang, Mingming ;

Zhao, Houli ;

Wei, Guoqing ;

Wang, Yiyun ;

Wu, Wenjun ;

Zhang, Yafei ;

Ni, Fang ;

Hu, Yongxian ;

Huang, He ;

Zhao, Kui .

FRONTIERS IN ONCOLOGY, 2021, 11

[43] A TIGIT-based chimeric co-stimulatory switch receptor improves T-cell anti-tumor function [J].

Hoogi, Shiran ;

Eisenberg, Vasyl ;

Mayer, Shimrit ;

Shamul, Astar ;

Barliya, Tilda ;

Cohen, Cyrille J. .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7 (01) :243

[44] TGF-β-responsive CAR-T cells promote anti-tumor immune function [J].

Hou, Andrew J. ;

Chang, ZeNan L. ;

Lorenzini, Michael H. ;

Zah, Eugenia ;

Chen, Yvonne Y. .

BIOENGINEERING & TRANSLATIONAL MEDICINE, 2018, 3 (02) :75-86

[45] Allogeneic Donor-Derived Anti-CD19 CAR T Cell Is a Promising Therapy for Relapsed/Refractory B-ALL After Allogeneic Hematopoietic Stem-Cell Transplantation [J].

Hua, Jingsheng ;

Zhang, Jian ;

Wu, Xiaoxia ;

Zhou, Lili ;

Bao, Xiebing ;

Han, Yue ;

Miao, Miao ;

Li, Caixia ;

Fu, Zhengzheng ;

Wu, Depei ;

Qian, Weiqing ;

Qiu, Huiying .

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2020, 20 (09) :610-616

[46] T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition [J].

Hui, Enfu ;

Cheung, Jeanne ;

Zhu, Jing ;

Su, Xiaolei ;

Taylor, Marcus J. ;

Wallweber, Heidi A. ;

Sasmal, Dibyendu K. ;

Huang, Jun ;

Kim, Jeong M. ;

Mellman, Ira ;

Vale, Ronald D. .

SCIENCE, 2017, 355 (6332) :1428-+

[47] Long-Term (≥4 Year and ≥5 Year) Overall Survival (OS) By 12-and 24-Month Event-Free Survival (EFS): An Updated Analysis of ZUMA-1, the Pivotal Study of Axicabtagene Ciloleucel (Axi- Cel) in Patients (Pts) with Refractory Large B-Cell Lymphoma (LBCL) [J].

Jacobson, Caron ;

Locke, Frederick L. ;

Ghobadi, Armin ;

Miklos, David B. ;

Lekakis, Lazaros J. ;

Oluwole, Olalekan O. ;

Lin, Yi ;

Hill, Brian T. ;

Timmerman, John M. ;

Deol, Abhinav ;

Reagan, Patrick M. ;

Stiff, Patrick ;

Flinn, Ian W. ;

Farooq, Umar ;

Goy, Andre H. ;

Munoz, Javier ;

Siddiqi, Tanya ;

Shen, Rhine R. ;

Bot, Adrian ;

Dong, Jinghui ;

Singh, Kanwarjit ;

Spooner, Clare ;

Karalliyadda, Roshan ;

Kim, Jenny J. ;

Zheng, Yan ;

Neelapu, Sattva S. .

BLOOD, 2021, 138 :1764-+

[48] Locally produced CD19 CAR T cells leading to clinical remissions in medullary and extramedullary relapsed acute lymphoblastic leukemia [J].

Jacoby, Elad ;

Bielorai, Bella ;

Avigdor, Abraham ;

Itzhaki, Orit ;

Hutt, Daphna ;

Nussboim, Vered ;

Meir, Amilia ;

Kubi, Adva ;

Levy, Michal ;

Zikich, Dragoslav ;

Zeltzer, Li-at ;

Brezinger, Karin ;

Schachter, Jacob ;

Nagler, Arnon ;

Besser, Michal J. ;

Toren, Amos .

AMERICAN JOURNAL OF HEMATOLOGY, 2018, 93 (12) :1485-1492

[49] CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity [J].

Jacoby, Elad ;

Nguyen, Sang M. ;

Fountaine, Thomas J. ;

Welp, Kathryn ;

Gryder, Berkley ;

Qin, Haiying ;

Yang, Yinmeng ;

Chien, Christopher D. ;

Seif, Alix E. ;

Lei, Haiyan ;

Song, Young K. ;

Khan, Javed ;

Lee, Daniel W. ;

Mackall, Crystal L. ;

Gardner, Rebecca A. ;

Jensen, Michael C. ;

Shern, Jack F. ;

Fry, Terry J. .

NATURE COMMUNICATIONS, 2016, 7

[50] Tumor interferon signaling and suppressive myeloid cells are associated with CAR T-cell failure in large B-cell lymphoma [J].

Jain, Michael D. ;

Zhao, Hua ;

Wang, Xuefeng ;

Atkins, Reginald ;

Menges, Meghan ;

Reid, Kayla ;

Spitler, Kristen ;

Faramand, Rawan ;

Bachmeier, Christina ;

Dean, Erin A. ;

Cao, Biwei ;

Chavez, Julio C. ;

Shah, Bijal ;

Lazaryan, Aleksandr ;

Nishihori, Taiga ;

Hussaini, Mohammed ;

Gonzalez, Ricardo J. ;

Mullinax, John E. ;

Rodriguez, Paulo C. ;

Conejo-Garcia, Jose R. ;

Anasetti, Claudio ;

Davila, Marco L. ;

Locke, Frederick L. .

BLOOD, 2021, 137 (19) :2621-2633

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