Listeriolysin is a potent inducer of the phosphatidylinositol response and lipid mediator generation in human endothelial cells

被引：51
作者：
Sibelius, U
Rose, F
Chakraborty, T
Darji, A
Wehland, J
Weiss, S
Seeger, W
Grimminger, F
机构：
[1] UNIV GIESSEN,DEPT INTERNAL MED,D-35392 GIESSEN,GERMANY
[2] UNIV GIESSEN,INST MED MICROBIOL,D-35392 GIESSEN,GERMANY
[3] NATL BIOTECHNOL CTR,DIV CELL BIOL & IMMUNOL,D-38124 BRAUNSCHWEIG,GERMANY
来源：
INFECTION AND IMMUNITY | 1996年 / 64卷 / 02期
关键词：
D O I：
10.1128/IAI.64.2.674-676.1996
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The impact of Listeria monocytogenes listeriolysin O (LLO) secretion on phosphoinositide metabolism and mediator (platelet-activating factor and prostaglandin I-2) generation was investigated in human umbilical vein endothelial cells. Wild-type L. monocytogenes, purified LLO, and an L. innocua strain engineered to secrete LLO all elicited a strong response, whereas mutant strains defective in LLO production were ineffective. Thus, human umbilical vein endothelial cell stimulation by listeriae is linked to production of LLO.
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页码：674 / 676
页数：3
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