1H, 13C and 15N resonance assignments of TbBDF5-bromo1 domain from Trypanosoma brucei

被引：0

作者：

Yang, Li ^{[1
]}

Zhang, Xiaole ^{[1
]}

Zhang, Jiahai ^{[1
]}

Tu, Xiaoming ^{[1
]}

机构：

[1] Univ Sci & Technol China, Sch Life Sci, MOE Key Lab Membraneless Organelles & Cellular Dy, Hefei 230027, Anhui, Peoples R China

来源：

BIOMOLECULAR NMR ASSIGNMENTS | 2022年 / 16卷 / 02期

关键词：

Trypanosoma brucei; Bromo domain; TbBDF5; Resonance assignment; BROMODOMAIN;

D O I：

10.1007/s12104-022-10088-1

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

H-1, C-13 and N-15 resonance assignments are presented for the first bromo domain of TbBDF5 (TbBDF5-bromo1) from Trypanosoma brucei. TbBDF5 is localized in the nucleus and plays a potential role in transcription regulation. Bromo domains can recognize acetylated histone through a conserved binding pocket. Here we report the NMR resonance assignments of TbBDF5-bromo1 domain for further studies of the relationship between its structure and function.

引用

收藏

页码：253 / 255

页数：3

相关论文

共 11 条

[1] NMRPIPE - A MULTIDIMENSIONAL SPECTRAL PROCESSING SYSTEM BASED ON UNIX PIPES [J].

DELAGLIO, F ;

GRZESIEK, S ;

VUISTER, GW ;

ZHU, G ;

PFEIFER, J ;

BAX, A .

JOURNAL OF BIOMOLECULAR NMR, 1995, 6 (03) :277-293

[2] Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family [J].

Filippakopoulos, Panagis ;

Picaud, Sarah ;

Mangos, Maria ;

Keates, Tracy ;

Lambert, Jean-Philippe ;

Barsyte-Lovejoy, Dalia ;

Felletar, Ildiko ;

Volkmer, Rudolf ;

Mueller, Susanne ;

Pawson, Tony ;

Gingras, Anne-Claude ;

Arrowsmith, Cheryl H. ;

Knapp, Stefan .

CELL, 2012, 149 (01) :214-231

[3] "Reading" a new chapter in protozoan parasite transcriptional regulation [J].

Fleck, Krista ;

Nitz, Malorie ;

Jeffers, Victoria .

PLOS PATHOGENS, 2021, 17 (12)

[4] Functions of bromodomain-containing proteins and their roles in homeostasis and cancer [J].

Fujisawa, Takao ;

Filippakopoulos, Panagis .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2017, 18 (04) :246-262

[5]

Goddard TD, 1993, SPARKY3

[6] Aim for the Readers! Bromodomains As New Targets Against Chagas' Disease [J].

Lucia Alonso, Victoria ;

Emilio Tavernelli, Luis ;

Pezza, Alejandro ;

Cribb, Pamela ;

Ritagliati, Carla ;

Serra, Esteban .

CURRENT MEDICINAL CHEMISTRY, 2019, 26 (36) :6544-6563

[7] Structure and function of bromodomains in chromatin-regulating complexes [J].

Marmorstein, R ;

Berger, SL .

GENE, 2001, 272 (1-2) :1-9

[8] Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome [J].

Schulz, Danae ;

Mugnier, Monica R. ;

Paulsen, Eda-Margaret ;

Kim, Hee-Sook ;

Chung, Chun-wa W. ;

Tough, David F. ;

Rioja, Inmaculada ;

Prinjha, Rab K. ;

Papavasiliou, F. Nina ;

Debler, Erik W. .

PLOS BIOLOGY, 2015, 13 (12)

[9] A systematic analysis of Trypanosoma brucei chromatin factors identifies novel protein interaction networks associated with sites of transcription initiation and termination [J].

Staneva, Desislava P. ;

Carloni, Roberta ;

Auchynnikava, Tatsiana ;

Tong, Pin ;

Rappsilber, Juri ;

Jeyaprakash, A. Arockia ;

Matthews, Keith R. ;

Allshire, Robin C. .

GENOME RESEARCH, 2021, 31 (11) :2138-2154

[10]

WISHART DS, 1994, J BIOMOL NMR, V4, P171