The role of IL-20 in chronic kidney disease and diabetic nephropathy: Pathogenic and therapeutic implications

被引：16

作者：

Chang, Ming-Shi ^{[1
]}

Hsu, Yu-Hsiang ^{[2
,3
]}

机构：

[1] Natl Cheng Kung Univ, Dept Biochem & Mol Biol, Coll Med, Tainan, Taiwan

[2] Natl Cheng Kung Univ, Inst Clin Med, Coll Med, Tainan 701, Taiwan

[3] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Clin Med Res Ctr, Tainan, Taiwan

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2018年 / 104卷 / 05期

关键词：

chronic kidney disease; diabetic nephropathy; IL-20; MONOCLONAL-ANTIBODY; INTERLEUKIN-20; CYTOKINES; INFLAMMATION; TARGETS; CELLS; DIFFERENTIATION; PROGRESSION; PSORIASIS; FIBROSIS;

D O I：

10.1002/JLB.MR1217-489R

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chronic kidney disease and its complications are a major public health problem worldwide. Diabetic nephropathy has become the main contributing cause of terminal renal failure. There are now evidences that different inflammatory molecules, including proinflammatory cytokines, play a critical role in the development of microvascular diabetic complications, including nephropathy. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, and renal failure. This review discusses the role of IL-20 as a pathogenic factor in renal injury, focusing on chronic kidney disease and diabetic nephropathy, and describes potential treatment strategies based on modulation of IL-20's function.

引用

页码：919 / 923

页数：5

共 51 条

[31] Interleukin-20 induced cell death in renal epithelial cells and was associated with acute renal failure [J].

Li, H-H ;

Hsu, Y-H ;

Wei, C-C ;

Lee, P-T ;

Chen, W-C ;

Chang, M-S .

GENES AND IMMUNITY, 2008, 9 (05) :395-404

[32] Interleukin-20 targets renal mesangial cells and is associated with lupus nephritis [J].

Li, Hsing-Hui ;

Cheng, He-Hsiung ;

Sun, Kuang-Hui ;

Wei, Chi-Chen ;

Li, Chien-Feng ;

Chen, Wen-Chung ;

Wu, Wen-Mein ;

Chang, Ming-Shi .

CLINICAL IMMUNOLOGY, 2008, 129 (02) :277-285

[33] Cellular and molecular mechanisms of renal fibrosis [J].

Liu, Youhua .

NATURE REVIEWS NEPHROLOGY, 2011, 7 (12) :684-696

[34]

Lopez-Giacoman Salvador, 2015, World J Nephrol, V4, P57, DOI 10.5527/wjn.v4.i1.57

[35] Inflammation and diabetic nephropathy [J].

Mora C. ;

Navarro J.F. .

Current Diabetes Reports, 2006, 6 (6) :463-468

[36] Cytokines: IL-20 - a new effector in skin inflammation [J].

Rich, BE ;

Kupper, TS .

CURRENT BIOLOGY, 2001, 11 (13) :R531-R534

[37] Efficacy and Safety of Anti-Interleukin-20 Monoclonal Antibody in Patients With Rheumatoid Arthritis A Randomized Phase IIa Trial [J].

Senolt, Ladislav ;

Leszczynski, Piotr ;

Dokoupilova, Eva ;

Goethberg, Marie ;

Valencia, Xavier ;

Hansen, Brian Bekker ;

Canete, Juan D. .

ARTHRITIS & RHEUMATOLOGY, 2015, 67 (06) :1438-1448

[38]

Shikata K, 2001, CONTRIB NEPHROL, V134, P46

[39] Transforming growth factor-β, basement membrane, and epithelial-mesenchymal transdifferentiation -: Implications for fibrosis in kidney disease [J].

Stahl, PJ ;

Felsen, D .

AMERICAN JOURNAL OF PATHOLOGY, 2001, 159 (04) :1187-1192

[40] Interleukin-20 plays a critical role in maintenance and development of psoriasis in the human xenograft transplantation model [J].

Stenderup, K. ;

Rosada, C. ;

Worsaae, A. ;

Dagnaes-Hansen, F. ;

Steiniche, T. ;

Hasselager, E. ;

Iversen, L. F. ;

Zahn, S. ;

Woldike, H. ;

Lindgreen Holmberg, H. ;

Romer, J. ;

Kragballe, K. ;

Clausen, J. T. ;

Dam, T. N. .

BRITISH JOURNAL OF DERMATOLOGY, 2009, 160 (02) :284-296

← 1 2 3 4 5 6 →