The role of IL-20 in chronic kidney disease and diabetic nephropathy: Pathogenic and therapeutic implications

被引：16

作者：

Chang, Ming-Shi ^{[1
]}

Hsu, Yu-Hsiang ^{[2
,3
]}

机构：

[1] Natl Cheng Kung Univ, Dept Biochem & Mol Biol, Coll Med, Tainan, Taiwan

[2] Natl Cheng Kung Univ, Inst Clin Med, Coll Med, Tainan 701, Taiwan

[3] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Clin Med Res Ctr, Tainan, Taiwan

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2018年 / 104卷 / 05期

关键词：

chronic kidney disease; diabetic nephropathy; IL-20; MONOCLONAL-ANTIBODY; INTERLEUKIN-20; CYTOKINES; INFLAMMATION; TARGETS; CELLS; DIFFERENTIATION; PROGRESSION; PSORIASIS; FIBROSIS;

D O I：

10.1002/JLB.MR1217-489R

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chronic kidney disease and its complications are a major public health problem worldwide. Diabetic nephropathy has become the main contributing cause of terminal renal failure. There are now evidences that different inflammatory molecules, including proinflammatory cytokines, play a critical role in the development of microvascular diabetic complications, including nephropathy. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, and renal failure. This review discusses the role of IL-20 as a pathogenic factor in renal injury, focusing on chronic kidney disease and diabetic nephropathy, and describes potential treatment strategies based on modulation of IL-20's function.

引用

页码：919 / 923

页数：5

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