Bactericidal effect of photodynamic therapy against methicillin-resistant Staphylococcus aureus strain with the use of various porphyrin photosensitizers

被引：46
作者：
Grinholc, Mariusz
Szramka, Bozena
Olender, Katarzyna
Graczyk, Alfreda
机构：
[1] Univ Gdansk, Med Univ Gdansk, Intercoll Fac Biotechnol, Dept Biotechnol,Div Mol Diagnost, PL-80822 Gdansk, Poland
[2] Mil Univ Technol, Inst Optoelect, Warsaw, Poland
来源：
ACTA BIOCHIMICA POLONICA | 2007年 / 54卷 / 03期
关键词：
MRSA; photodynamic therapy; photosensitizer; porphyrin;
D O I：
10.18388/abp.2007_3240
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Photodynamic therapy (PDT) is based on photosensitizers activated by light of appropriate wavelength. Their activation leads to generation of singlet oxygen and free radicals responsible for the cytotoxic effect. The aim of this project was to compare the bactericidal effect of PDT using different porphyrin photosensitizers against a methicillin-resistant Staphylococcus aureus strain. Exogenous sensitizers (protoporphyrin IX and newly synthesized derivative, protoporphyrin diarginate) induced a 3 log(10)-unit reduction in bacterial viable counts. With the use of endogenous, ALA-induced porphyrins, a 1.6 log(10)-unit reduction was obtained. The sensitizers tested executed their antibacterial activity with no essential change in the antibiotic resistance pattern of the studied strain.
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页码：665 / 670
页数：6
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