New fused benzazepine as selective D3 receptor antagonists.: Synthesis and biological evaluation.: Part 2:: [g]-Fused and hetero-fused systems

被引：14

作者：

Micheli, Fabrizio ^{[1
]}

Bonanomi, Giorgio ^{[1
]}

Braggio, Simone ^{[1
]}

Capelli, Anna Maria ^{[2
]}

Damiani, Federica ^{[3
]}

Di Fabio, Romano ^{[1
]}

Donati, Daniele ^{[1
]}

Gentile, Gabriella ^{[1
]}

Hamprecht, Dieter ^{[1
]}

Perini, Ornella ^{[2
]}

Petrone, Marcella ^{[1
]}

Tedesco, Giovanna ^{[2
]}

Terreni, Silvia ^{[1
]}

Worby, Angela

Heidbreder, Christian ^{[1
]}

机构：

[1] GlaxoSmithKline Inc, Psychiat Ctr Excellence Drug Discovery, I-37135 Verona, Italy

[2] Mol Discovery Res, I-37135 Verona, Italy

[3] European Patent Off, Munich, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 03期

关键词：

rat; dopamine; D-3; antagonists; selective; drug dependence;

D O I：

10.1016/j.bmcl.2007.12.042

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and the SAR of a new series of potent and selective dopamine D-3 receptor antagonists is reported. The new scaffolds of the [g]-fused and the hetero-fused tricyclic benzazepine are here reported together with their pharmacokinetic profile. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：908 / 912

页数：5

共 6 条

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