Complex alternative splicing

被引：31

作者：

Park, Jung Woo ^{[1
]}

Graveley, Brenton R. ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, Farmington, CT 06030 USA

来源：

ALTERNATIVE SPLICING IN THE POSTGENOMIC ERA | 2007年 / 623卷

关键词：

PRE-MESSENGER-RNA; DROSOPHILA-DSCAM; AXON GUIDANCE; MOLECULAR DIVERSITY; LOLA ENCODES; BRANCH POINT; GENE; GENOME; EXONS; TRANSCRIPTION;

D O I：

10.1007/978-0-387-77374-2_4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Alternative splicing is a powerful means of controlling gene expression and increasing protein diversity. Most genes express a limited number of mRNA isoforms, but there are several examples of genes that use alternative splicing to generate hundreds, thousands and even tens of thousands of isoforms. Collectively such genes are considered to undergo complex alternative splicing. The best example is the Drosophila Down syndrome cell adhesion molecule (Dscam) gene, which can generate 38,016 isoforms by the alternative splicing of 95 variable exons. In this review, we will describe several genes that use complex alternative splicing to generate large repertoires of mRNAs and what is known about the mechanisms by which they do so.

引用

页码：50 / 63

页数：14