Review article: the epidemiologic burden of non-alcoholic fatty liver disease across the world

被引:150
作者
Henry, Linda [1 ]
Paik, James [2 ]
Younossi, Zobair M. [3 ]
机构
[1] Inova Fairfax Med Campus, Dept Med, Ctr Liver Dis, Falls Church, VA USA
[2] Inova Hlth Syst, Betty & Guy Beatty Ctr Integrated Res, Falls Church, VA USA
[3] Ctr Outcomes Res Liver Dis, Washington, DC USA
关键词
UNITED-STATES; METABOLIC SYNDROME; FIBROSIS STAGE; RISK-FACTORS; PREVALENCE; STEATOHEPATITIS; SEVERITY; OUTCOMES; ASSOCIATION; NAFLD;
D O I
10.1111/apt.17158
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing in parallel to obesity and type 2 diabetes mellitus epidemics. Aim To provide a narrative review on NAFLD global epidemiology. Methods We retrieved articles from PubMed using search terms of NAFLD, epidemiology, prevalence, incidence, and comorbidities. Results Over 250 articles were reviewed. In 2016, the global NAFLD prevalence was 25%; this increased to >30% in 2019. The NAFLD prevalence in Asia, Latin America and Middle East-North Africa (MENA) was 30.8%, 34.5% and 42.6%, respectively. These prevalence rates increased with age. Although the NAFLD prevalence is higher in men, the prevalence rates for post-menopausal women are similar. NAFLD prevalence is higher in certain subpopulations, especially among the obese and those with metabolic syndrome (MS), while the prevalence of lean NAFLD is 11.2%. The global prevalence of non-alcoholic steatohepatitis (NASH) is estimated between 2% and 6% in the general population. Approximately 7% of NAFLD patients have advanced fibrosis but with rates between 21% and 50% among NASH patients. Overall mortality related to NAFLD is 15-20 cases per 1000 person-years, and increases substantially in NASH patients, especially with components of MS. Recent data suggest mortality/morbidity from NAFLD is increasing globally but NAFLD awareness remains low among patients and healthcare providers. Conclusions NAFLD poses a global public health problem with a very high disease burden in Asia, MENA and Latin America. Research is needed to better quantify the full impact of NAFLD and to develop strategies to improve awareness and risk stratification for this important liver disease.
引用
收藏
页码:942 / 956
页数:15
相关论文
共 154 条
[91]  
Sanyaolu Adekunle, 2019, Glob Pediatr Health, V6, p2333794X19891305, DOI 10.1177/2333794X19891305
[92]   Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in the United States and the Rest of the World [J].
Sayiner, Mehmet ;
Koenig, Aaron ;
Henry, Linda ;
Younossi, Zobair M. .
CLINICS IN LIVER DISEASE, 2016, 20 (02) :205-+
[93]   Disease burden and economic impact of diagnosed non-alcoholic steatohepatitis in five European countries in 2018: A cost-of-illness analysis [J].
Schattenberg, Jorn M. ;
Lazarus, Jeffrey V. ;
Newsome, Philip N. ;
Serfaty, Lawrence ;
Aghemo, Alessio ;
Augustin, Salvador ;
Tsochatzis, Emmanuel ;
de Ledinghen, Victor ;
Bugianesi, Elisabetta ;
Romero-Gomez, Manuel ;
Bantel, Heike ;
Ryder, Stephen D. ;
Boursier, Jerome ;
Leroy, Vincent ;
Crespo, Javier ;
Castera, Laurent ;
Floros, Lefteris ;
Atella, Vincenzo ;
Mestre-Ferrandiz, Jorge ;
Elliott, Rachel ;
Kautz, Achim ;
Morgan, Alice ;
Sansom, Sally L. ;
Vasudevan, Sharad ;
Pezzullo, Lynne ;
Trylesinski, Aldo ;
Cure, Sandrine ;
Higgins, Victoria ;
Ratziu, Vlad .
LIVER INTERNATIONAL, 2021, 41 (06) :1227-1242
[94]   Prevalence of fatty liver in children and adolescents [J].
Schwimmer, Jeffrey B. ;
Deutsch, Reena ;
Kahen, Tanaz ;
Lavine, Joel E. ;
Stanley, Christina ;
Behling, Cynthia .
PEDIATRICS, 2006, 118 (04) :1388-1393
[95]   Nonalcoholic Fatty Liver Disease in Children Hepatic and Extrahepatic Complications [J].
Selvakumar, Praveen Kumar Conjeevaram ;
Kabbany, Mohammad Nasser ;
Nobili, Valerio ;
Alkhouri, Naim .
PEDIATRIC CLINICS OF NORTH AMERICA, 2017, 64 (03) :659-+
[96]   The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 [J].
Sepanlou, Sadaf G. ;
Safiri, Saeid ;
Bisignano, Catherine ;
Ikuta, Kevin S. ;
Merat, Shahin ;
Saberifiroozi, Mehdi ;
Poustchi, Hossein ;
Tsoi, Derrick ;
Colombara, Danny V. ;
Abdoli, Amir ;
Adedoyin, Rufus Adesoji ;
Afarideh, Mohsen ;
Agrawal, Sutapa ;
Ahmad, Sohail ;
Ahmadian, Elham ;
Ahmadpour, Ehsan ;
Akinyemiju, Tomi ;
Akunna, Chisom Joyqueenet ;
Alipour, Vahid ;
Almasi-Hashiani, Amir ;
Almulhim, Abdulaziz M. ;
Al-Raddadi, Rajaa M. ;
Alvis-Guzman, Nelson ;
Anber, Nahla Hamed ;
Angus, Colin ;
Anoushiravani, Amir ;
Arabloo, Jalal ;
Araya, Ephrem Mebrahtu ;
Asmelash, Daniel ;
Ataeinia, Bahar ;
Ataro, Zerihun ;
Atout, Maha Moh'd Wahbi ;
Ausloos, Floriane ;
Awasthi, Ashish ;
Badawi, Alaa ;
Banach, Maciej ;
Bejarano Ramirez, Diana Fernanda ;
Bhagavathula, Akshaya Srikanth ;
Bhala, Neeraj ;
Bhattacharyya, Krittika ;
Biondi, Antonio ;
Bolla, Srinivasa Rao ;
Boloor, Archith ;
Borzi, Antonio M. ;
Butt, Zahid A. ;
Alberto Camera, Luis L. A. ;
Campos-Nonato, Ismael R. ;
Carvalho, Felix ;
Dinh-Toi Chu ;
Chung, Sheng-Chia .
LANCET GASTROENTEROLOGY & HEPATOLOGY, 2020, 5 (03) :245-266
[97]   Prevalence of Chronic Liver Disease and Cirrhosis by Underlying Cause in Understudied Ethnic Groups: The Multiethnic Cohort [J].
Setiawan, Veronica Wendy ;
Stram, Daniel O. ;
Porcel, Jacqueline ;
Lu, Shelly C. ;
Le Marchand, Loic ;
Noureddin, Mazen .
HEPATOLOGY, 2016, 64 (06) :1969-1977
[98]   Sex-Specific Differences in the Association Between Race/Ethnicity and NAFLD Among US Population [J].
Shaheen, Magda ;
Schrode, Katrina M. ;
Pan, Deyu ;
Kermah, Dulcie ;
Puri, Vishwajeet ;
Zarrinpar, Ali ;
Elisha, David ;
Najjar, Sonia M. ;
Friedman, Theodore C. .
FRONTIERS IN MEDICINE, 2021, 8
[99]   Prevalence of Non-alcoholic Fatty Liver Disease in India: A Systematic Review and Meta-analysis [J].
Shalimar ;
Elhence, Anshuman ;
Bansal, Bhavik ;
Gupta, Hardik ;
Anand, Abhinav ;
Singh, Thakur P. ;
Goel, Amit .
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY, 2022, 12 (03) :818-829
[100]   Cancer Risk in Patients With Biopsy-Confirmed Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study [J].
Simon, Tracey G. ;
Roelstraete, Bjorn ;
Sharma, Rajani ;
Khalili, Hamed ;
Hagstrom, Hannes ;
Ludvigsson, Jonas F. .
HEPATOLOGY, 2021, 74 (05) :2410-2423