Mechanisms mediating renal sympathetic nerve activation in obesity-related hypertension

被引：0
作者：
Chen, W. [1 ]
Leo, S. [1 ]
Weng, C. [1 ]
Yang, X. [1 ]
Wu, Y. [1 ]
Tang, X. [1 ]
机构：
[1] Cent S Univ, Dept Cardiol, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China
来源：
HERZ | 2015年 / 40卷
基金：
高等学校博士学科点专项科研基金;
关键词：
Renal sympathetic nerve activity; Baroreflex sensitivity; Obesity; Denervation; Hypertension; RENIN-ANGIOTENSIN SYSTEM; AMBULATORY BLOOD-PRESSURE; METABOLIC SYNDROME; ADIPOSE-TISSUE; BAROREFLEX SENSITIVITY; ARTERIAL-PRESSURE; PLASMA LEPTIN; II INFUSION; INSULIN; DENERVATION;
D O I：
10.1007/s00059-014-4072-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Excessive renal sympathetic nerve activation may be one of the mechanisms underlying obesity-related hypertension. Impaired baroreflex sensitivity, adipokine disorders-such as leptin, adiponectin, and resistin-activation of the renin-angiotensin system, hyperinsulinemia, insulin resistance, and renal sodium retention present in obesity increase renal sympathetic nerve activity, thus contributing to the development of hypertension. Renal sympathetic denervation reduces both renal sympathetic activity and blood pressure in patients with obesity-related hypertension.
引用
收藏
页码：190 / 196
页数：7
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