Anti-Oxidative Effect of Lipoic Acid in Spinal Cord Ischemia/Reperfusion

被引：32

作者：

Shaafi, Sheyda ^{[2
]}

Afrooz, Mohammad Razm ^{[2
]}

Hajipour, Babak ^{[1
]}

Dadadshi, Alireza ^{[3
]}

Hosseinian, Mohammad Mehdi ^{[1
]}

Khodadadi, Ali ^{[4
]}

机构：

[1] Islamic Azad Univ, Fac Med, Dept Neurol, Tabriz City, Iran

[2] Tabriz Univ Med Sci, Neurosci Res Ctr, Tabriz, Iran

[3] Army Univ Med Sci, Fac Med, Dept Infect Dis, Tabriz, Iran

[4] Islamic Azad Univ Tehran, Sci & Res Branch, Dept Vet Clin Pathol, Tehran, Iran

来源：

MEDICAL PRINCIPLES AND PRACTICE | 2011年 / 20卷 / 01期

关键词：

Ischemia/reperfusion; Lipoic acid; Spine; THORACOABDOMINAL AORTIC-ANEURYSM; SUPEROXIDE-DISMUTASE; REPERFUSION INJURY; ISCHEMIA; RABBITS; REPAIR; ALLOPURINOL; PARAPLEGIA; PREVENTION; SURGERY;

D O I：

10.1159/000319772

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Lipoic acid (LA) is an effective anti-oxidant agent that can scavenge free radicals in biological systems. The aim of this research was to study the probable protective effect of LA in spinal ischemic/reperfusion (I/R) injury. Materials and Methods: Thirty male Wistar rats, weighing 230-285 g, were assigned randomly into 3 groups (10 animals in each group): sham spinal I/R, and spinal I/R + LA. The spinal I/R + LA rats received LA 100 mg/kg subcutaneously 3 days prior to ischemia induction and 3 days after. The induction of ischemia lasted for 30 min. Results: At 72 h postoperatively, the neurological status was worse in the I/R group than the sham group (p < 0.05). The neurological status of animals in the LA-treated group appeared better than the I/R group (p < 0.05). In the I/R group, tissue glutathione peroxidase (GPx) and super oxide dismutase (SOD) activity were significantly less compared to the control group (p < 0.05). In the LA-treated group, tissue GPx and SOD levels were higher compared to the I/R group (p < 0.05). Conclusions: LA pretreatment reduced neurologic injury in the rats, most probably by maintaining the oxidant/anti-oxidant ion balance during spinal cord ischemia. Reperfusion may have contributed to the protective effects seen in the LA pretreatment. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：19 / 22

页数：4

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