New TRP channels in hearing and mechanosensation

被引：110

作者：

Corey, DP ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA

来源：

NEURON | 2003年 / 39卷 / 04期

关键词：

D O I：

10.1016/S0896-6273(03)00505-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Despite extensive biophysical characterization and the superb example of the bacterial MscL channel, molecular identification of eukaryotic mechanosensitive channels has been slow. New members of the TRP superfamily have emerged as candidate channels to mediate touch, hearing, fluid flow, and osmosensation in sensory and nonsensory cells. Distinguishing between direct mechanical activation and indirect second messenger activation is still a challenge.

引用

页码：585 / 588

页数：4

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