L-Dopa effect on frequency-dependent depression of the H-reflex in adult rats with complete spinal cord transection

被引：9

作者：

Liu, Hao ^{[1
]}

Skinner, Robert D. ^{[2
]}

Arfaj, Ahmad ^{[1
]}

Yates, Charlotte ^{[1
]}

Reese, Nancy B. ^{[1
]}

Williams, Keith ^{[3
]}

Garcia-Rill, Edgar ^{[2
]}

机构：

[1] Univ Cent Arkansas, Dept Phys Therapy, Conway, AR 72035 USA

[2] Univ Arkansas Med Sci, Dept Neurobiol & Dev Sci, Ctr Translat Neurosci, Little Rock, AR 72205 USA

[3] Univ Arkansas Med Sci, Dept Biostat, Little Rock, AR 72205 USA

来源：

BRAIN RESEARCH BULLETIN | 2010年 / 83卷 / 05期

关键词：

H reflex; Hyperreflexia; Spasticity; Spinal cord injury; Exercise; DOPA; Low frequency dependent depression; MOTOR CORTEX INJURY; LOCOMOTOR FUNCTION; PROMOTES RECOVERY; PASSIVE EXERCISE; AMPHETAMINE; CAT; CATECHOLAMINES; HYPERREFLEXIA; PATTERNS; DECARBOXYLASE;

D O I：

10.1016/j.brainresbull.2010.07.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study investigated whether L-dopa (DOPA) locomotor-like passive exercise (Ex) using a motorized bicycle exercise trainer (MBET) or their combination in adult rats with complete spinal cord transection (Tx) preserves and restores low frequency-dependent depression (FDD) of the H-reflex Adult Sprague-Dawley rats (n = 56) transected at T8-9 had one of five treatments beginning 7 days after transection Tx (transection only) Tx + Ex Tx + DOPA Tx + Ex + DOPA and control (Ctl no treatment) groups After 30 days of treatment FDD of the H-reflex was tested Stimulation of the tibial nerve at 02 1 5 and 10 Hz evoked an H-reflex that was recorded from plantar muscles of the hind paw No significant differences were found at the stimulation rate of 1 Hz However at 5 Hz FDD of the H-reflex in the Tx + Ex Tx + DOPA and Ctl groups was significantly different from the Tx group (p < 0 01) At 10 Hz all of the treatment groups were significantly different from the Tx group (p < 0 01) No significant difference was identified between the Ctl and any of the treatment groups These results suggest that DOPA significantly preserved and restored FDD after transection as effectively as exercise alone or exercise in combination with DOPA Thus there was no additive benefit when DOPA was combined with exercise (C) 2010 Elsevier Inc All rights reserved

引用

页码：262 / 265

页数：4

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