Global, regional, and national burden of congenital heart disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

被引：501

作者：

Zimmerman, Meghan S. ^{[1
,2
,3
]}

Smith, Alison Grace Carswell ^{[4
]}

Sable, Craig A. ^{[3
]}

Echko, Michelle Marie ^{[5
]}

Wilner, Lauren B. ^{[5
]}

Olsen, Helen Elizabeth ^{[9
]}

Atalay, Hagos Tasew ^{[10
]}

Awasthi, Ashish ^{[11
,12
]}

Bhutta, Zulfiqa R. A. ^{[13
,14
]}

Boucher, Jackie LeeAnne ^{[15
]}

Castro, Franz ^{[16
]}

Cortesi, Paolo Angelo ^{[17
]}

Dubey, Manisha ^{[18
]}

Fischer, Florian ^{[19
]}

Lamidi, Samer, I

Hay, Simon, I ^{[5
,6
]}

Hoang, Chi Linh ^{[20
]}

Hugo-Hainrnan, Christopher Thomas ^{[21
,23
,24
]}

Jenkins, Kathy J. ^{[25
,26
]}

Kar, Anita ^{[27
,28
]}

Khalil, Ibrahim A. ^{[5
,6
]}

Kumar, Raman Krishna ^{[12
,29
]}

Kwan, Gene F. ^{[30
,31
]}

Mengistu, Desalegn Tadese ^{[32
]}

Mokdad, Ali H. ^{[5
,6
]}

Naghavi, Mohsen ^{[5
,6
]}

Negesa, Lemma ^{[34
]}

Negoi, Ionut ^{[35
]}

Negoi, Ruxandra Irina ^{[36
,37
]}

Nguyen, Cuong Tat ^{[38
]}

Huong Lan Thi Nguyen ^{[38
]}

Long Hoang Nguyen ^{[20
]}

Son Hoang Nguyen ^{[20
]}

Trang Huyen Nguyen ^{[20
]}

Nixon, Molly R. ^{[5
]}

Noubiap, Jean Jacques ^{[22
]}

Patel, Shanti ^{[39
]}

Peprah, Emmanuel K. ^{[40
]}

Reiner, Robert C. ^{[5
,6
]}

Roth, Gregory A. ^{[5
,7
]}

Ternsah, Moharnad-Hani ^{[41
,42
]}

Tovani-Palone, Marcos Roberto ^{[43
]}

Towbin, Jeffrey A. ^{[44
]}

Tran, Bach Xuan ^{[45
]}

Tung Thanh Tran ^{[38
]}

Nu Thi Truong ^{[20
]}

Vos, Theo ^{[5
,6
]}

Vosoughi, Kia ^{[46
,47
]}

Weintraub, Robert G. ^{[48
,49
]}

Weldegwergs, Kidu Gidey ^{[33
]}

机构：

[1] Dartmouth Hitchcock Med Ctr, Div Pediat Cardiol, Lebanon, NH 03766 USA

[2] George Washington Univ, Milken Inst Sch Publ Hlth, Washington, DC USA

[3] Childrens Natl Hlth Syst, Dept Cardiol, Washington, DC 20010 USA

[4] Emory Univ, Sch Med, Atlanta, GA USA

[5] Univ Washington, Inst Hlth Metr Arid Evaluat, Seattle, WA 98195 USA

[6] Univ Washington, Sch Med, Dept Hlth Metr Sci, Seattle, WA USA

[7] Univ Washington, Div Cardiol, Seattle, WA 98195 USA

[8] Univ Washington, Dept Anesthesiol & Pain Med, Seattle, WA 98195 USA

[9] Bill & Melinda Gates Fdn, Dept Global Hlth, Seattle, WA USA

[10] Aksum Univ, Dept Nursing, Aksum, Tigray, Ethiopia

[11] Indian Inst Publ Hlth, Gandhinagar, Gujarat, India

[12] Publ Hlth Fdn India, Gurugram, Haryana, India

[13] Univ Toronto, Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada

[14] Aga Khan Univ, Ctr Excellence Women & Child Hlth, Karachi, Sindh, Pakistan

[15] Childrens HeartLink, Dept Adm, Edina, MN USA

[16] Gorgas Mem Inst Hlth Studies, Dept Res & Hlth Technol Assessment, Panama City, Panama

[17] Univ Milano Bicocca, Sch Med & Surg, Monza, Italy

[18] UN, World Food Programme, New Delhi, India

[19] Bielefeld Univ, Dept Publ Hlth Med, Bielefeld, Germany

[20] Nguyen Tat Thanh Univ, Ctr Excellence Behav Med, Ho Chi Minh City, Vietnam

[21] Dept Pediat & Child Hlth, Cape Town, South Africa

[22] Dept Med, Cape Town, South Africa

[23] Univ Cape Town, Cape Town, South Africa

[24] Pediat Cardiol, Windhoek, Namibia

[25] Boston Childrens Hosp, Ctr Appl Pediat Qual Analyt, Boston, MA USA

[26] Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA

[27] Savitribai Phule Pune Univ, Sch Hlth Sci, Pune, Maharashtra, India

[28] Birth Defects & Childhood Disabil Res Ctr, Pune, Maharashtra, India

[29] Amrita Inst Med Sci, Dept Pediat Cardiol, Ernakulam, India

[30] Boston Univ, Sch Med, Boston, MA 02118 USA

[31] Partners In Hlth, Boston, MA USA

[32] Mekelle Univ, Sch Med, Mekelle, Ethiopia

[33] Mekelle Univ, Clin Pharm Unit, Mekelle, Ethiopia

[34] Haramaya Univ, Harar, Ethiopia

[35] Carol Davila Univ Med & Pharm, Emergency Hosp Bucharest, Bucharest, Romania

[36] Carol Davila Univ Med & Pharm, Anat & Embryol Dept, Bucharest, Romania

[37] Cardio Aid, Dept Cardiol, Bucharest, Romania

[38] Duy Tan Univ, Inst Global Hlth Innovat, Hanoi, Vietnam

[39] Maimonides Hosp, Dept Med, Brooklyn, NY 11219 USA

[40] NYU, Dept Social & Behav Sci, New York, NY USA

[41] King Saud Univ, Dept Pediat, Riyadh, Saudi Arabia

[42] Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia

[43] Univ Sao Paulo, Dept Pathol & Legal Med, Ribeirao Preto, Brazil

[44] Univ Tennessee, Dept Pediat, Memphis, TN USA

[45] Hanoi Med Univ, Dept Hlth Econ, Hanoi, Vietnam

[46] Johns Hopkins Univ, Dept Gastroenterol & Hepatol, Baltimore, MD USA

[47] Iran Univ Med Sci, Prevent Med & Publ Hlth Res Ctr, Tehran, Iran

[48] Royal Childrens Hosp, Cardiol Dept, Melbourne, Vic, Australia

[49] Murdoch Childrens Res Inst, Melbourne, Vic, Australia

[50] ACS Med Coll & Hosp, Algiers, Algeria

来源：

LANCET CHILD & ADOLESCENT HEALTH | 2020年 / 4卷 / 03期

关键词：

VENTRICULAR SEPTAL-DEFECTS; NEURODEVELOPMENTAL OUTCOMES; GENERAL-POPULATION; CARDIAC-DISEASE; TEMPORAL TRENDS; PREVALENCE; SURGERY; MORTALITY; SURVIVAL; CHILDREN;

D O I：

10.1016/S2352-4642(19)30402-X

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background Previous congenital heart disease estimates came from few data sources, were geographically narrow, and did not evaluate congenital heart disease throughout the life course. Completed as part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2017, this study aimed to provide comprehensive estimates of congenital heart disease mortality, prevalence, and disability by age for 195 countries and territories from 1990 to 2017. Methods Mortality estimates were generated for aggregate congenital heart disease and non-fatal estimates for five subcategories (single ventricle and single ventricle pathway congenital heart anomalies; severe congenital heart anomalies excluding single ventricle heart defects; critical malformations of great vessels, congenital valvular heart disease, and patent ductus arteriosus; ventricular septal defect and atrial septal defect; and other congenital heart anomalies), for 1990 through to 2017. All available global data were systematically analysed to generate congenital heart disease mortality estimates (using Cause of Death Ensemble modelling) and prevalence estimates (DisMod-MR 2.1). Systematic literature reviews of all types of congenital anomalies to capture information on prevalence, associated mortality, and long-term health outcomes on congenital heart disease informed subsequent disability estimates. Findings Congenital heart disease caused 261 247 deaths (95% uncertainty interval 216 567-308 159) globally in 2017, a 34.5% decline from 1990, with 180 624 deaths (146 825-214 178) being among infants (aged <1 years). Congenital heart disease mortality rates declined with increasing Socio-demographic Index (SDI); most deaths occurred in countries in the low and low-middle SDI quintiles. The prevalence rates of congenital heart disease at birth changed little temporally or by SDI, resulting in 11 998 283 (10 958 658-13 123 888) people living with congenital heart disease globally, an 18.7% increase from 1990 to 2017, and causing a total of 589 479 (287 200-973 359) years lived with disability. Interpretation Congenital heart disease is a large, rapidly emerging global problem in child health. Without the ability to substantially alter the prevalence of congenital heart disease, interventions and resources must be used to improve survival and quality of life. Our findings highlight the large global inequities in congenital heart disease and can serve as a starting point for policy changes to improve screening, treatment, and data collection. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd.

引用

页码：185 / 200

页数：16

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