Alpha-synuclein modulates dopamine neurotransmission

被引：47

作者：

Butler, Brittany

Sambo, Danielle

Khoshbouei, Habibeh ^{[1
]}

机构：

[1] Univ Florida, Dept Neurosci, POB 100244, Gainesville, FL 32611 USA

来源：

JOURNAL OF CHEMICAL NEUROANATOMY | 2017年 / 83卷

关键词：

TRANSPORTER KNOCKOUT MICE; MULTIPLE SYSTEM ATROPHY; VESICULAR MONOAMINE TRANSPORTER; DEFICIT HYPERACTIVITY DISORDER; FAMILIAL PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; IN-VITRO; TRANSGENIC MOUSE; FIBRIL FORMATION; LEWY BODIES;

D O I：

10.1016/j.jchemneu.2016.06.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alpha-synuclein is a small, highly charged protein encoded by the synuclein or SNCA gene that is predominantly expressed in central nervous system neurons. Although its physiological function remains enigmatic, alpha-synuclein is implicated in movement disorders such as Parkinson's disease, multiple system atrophy, and in neurodegenerative diseases such as Dementia with Lewy bodies. Here we have focused on reviewing the existing literature pertaining to wild-type alpha-synuclein structure, its properties, and its potential involvement in regulation of dopamine neurotransmission. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：41 / 49

页数：9

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