Cannabinoid receptor 2 deletion influences social memory and synaptic architecture in the hippocampus

被引:11
作者
Komorowska-Mueller, Joanna Agnieszka [1 ]
Ravichandran, Kishore Aravind [1 ]
Zimmer, Andreas [1 ]
Schuermann, Britta [1 ]
机构
[1] Univ Bonn, Univ Hosp Bonn, Med Fac, Inst Mol Psychiat, Venusberg Campus 1,Bldg 76, D-53127 Bonn, Germany
关键词
ALZHEIMERS-DISEASE; CB2; RECEPTORS; MOUSE MODEL; MICE; PLASTICITY; DEFICIENCY; ACTIVATION; EXPRESSION; INHIBITION; MODULATION;
D O I
10.1038/s41598-021-96285-9
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Although the cannabinoid receptor 2 (CB2R) is often thought to play a role mainly outside the brain several publications unequivocally showed the presence of CB2R on hippocampal principal neurons. Activation of CB2R produced a long-lasting membrane potential hyperpolarization, altered the input/output function of CA2/3 principal neurons and produced alterations in gamma oscillations. However, other cellular, molecular and behavioral consequences of hippocampal CB2R signaling have not been studied in detail. Here we demonstrate that the deletion of CB2 leads to a highly significant increase in hippocampal synapsin-I expression levels and particle density, as well as increased vesicular GABA transporter (vGAT) levels. This phenotype was restricted to females and not observed in males. Furthermore, we demonstrate an impairment of social memory in CB2 deficient mice. Our results thus demonstrate that the lack of CB2R leads to changes in the hippocampal synaptic landscape and reveals an important sex-specific difference in endocannabinoid signaling. This study supports a significant role of the CB2R in modulation of different types of memory despite its low expression levels in the brain and provides more insight into a sex-specific role of CB2R in synaptic architecture.
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页数:10
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