Synthetic catalysis of amide isomerization

被引：100

作者：

Cox, C ^{[1
]}

Lectka, T ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2000年 / 33卷 / 12期

关键词：

D O I：

10.1021/ar990165g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rotation about the C-N bond in amides can be catalyzed by Bronsted and Lewis acids, as well as nucleophiles and bases. Catalysis of amide isomerization occurs in biological systems via "rotamase" enzymes; however, the mechanisms by which these proteins operate are not completely understood. We outline investigations that provide experimental support for mechanisms believed to be feasible for the catalysis of amide isomerization and present practical applications that have resulted from this work.

引用

页码：849 / 858

页数：10

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