Functional and dysfunctional roles of quadruplex DNA in cells

被引：155

作者：

Arthanari, H ^{[1
]}

Bolton, PH ^{[1
]}

机构：

[1] Wesleyan Univ, Dept Chem, Middletown, CT 06459 USA

来源：

CHEMISTRY & BIOLOGY | 2001年 / 8卷 / 03期

关键词：

quadruplex DNA; G4; DNA; telomere; Bloom's syndrome; Werner's syndrome; triplet repeat; telomerase;

D O I：

10.1016/S1074-5521(01)00007-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A number of biological roles have been proposed for quadruplex, also referred to as G4 or tetraplex, DNA. The presence of quadruplex DNA may lead to errors in some biological processes and be required in others. Proteins that interact with quadruplex DNA have been identified including those that cause Bloom's and Werner's syndromes. There are small molecules that specifically bind to quadruplex DNA, inhibit telomerase, and are cytotoxic towards tumor cells indicating a role for quadruplex DNA in telomere function. It is now possible to make testable proposals for the possible biological implications of quadruplex DNA in replication, transcription: and recombination as well as possible routes to therapeutic intervention. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：221 / 230

页数：10

共 82 条

[1] Porphyrin binding to quadruplexed T4G4 [J].