Sex, but not maternal protein or folic acid intakes determines the fatty acid composition of hepatic phospholipids, but not of triacylglycerol, in adult rats

被引：46

作者：

Burdge, G. C. ^{[1
]}

Slater-Jefferies, J. L. ^{[2
]}

Grant, R. A. ^{[1
]}

Chung, W. -S. ^{[1
]}

West, A. L. ^{[1
]}

Lillycrop, K. A. ^{[1
]}

Hanson, M. A. ^{[2
]}

Calder, P. C. ^{[1
]}

机构：

[1] Univ Southampton, Southampton Gen Hosp, Inst Human Nutr, Inst Dev Sci Bldg, Southampton SO16 6YD, Hants, England

[2] Univ Southampton, Ctr Dev Origins Hlth & Dis, Southampton SO16 6YD, Hants, England

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2008年 / 78卷 / 01期

关键词：

D O I：

10.1016/j.plefa.2007.10.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of the study was to investigate whether the protein and folic acid content of the maternal diet and the sex of the offspring alter the polyunsaturated fatty acid content of hepatic phospholipids and triacylglycerol (TAG). Pregnant rats were fed diets containing 18% or 9% protein with either 1 or 5 mg/kg folic acid. Maternal diet did not alter hepatic lipid composition in the adult offspring. Data from each maternal dietary group were combined and reanalysed. The proportion of 18:0, 20:4n-6 and 22:6n-3 in liver phospholipids was higher in females than in males, while hepatic TAG composition did not differ between sexes. Delta 5 Desaturase expression was higher in females than in males. Neither Delta 5 nor Delta 6 desaturase expression was related to polyunsaturated fatty acid concentrations. These results suggest that sex differences in liver phospholipid fatty acid composition may reflect primary differences in the specificity of phospholipid biosynthesis. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：73 / 79

页数：7

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