Gene signatures in hepatocellular carcinoma (HCC)

被引：41
作者：
Andrisani, Ourania M. [1 ,2 ]
Studach, Leo [1 ,2 ]
Merle, Philippe [3 ,4 ]
机构：
[1] Purdue Univ, Basic Med Sci Dept, W Lafayette, IN 47907 USA
[2] Purdue Univ, Purdue Ctr Canc Res, W Lafayette, IN 47907 USA
[3] Univ Lyon 1, INSERM, Lyon Est IFR62, U871, F-69008 Lyon, France
[4] Hop Hotel Dieu, Hosp Civils Lyon, Serv Hepatol & Gastroenterol, F-69002 Lyon, France
来源：
SEMINARS IN CANCER BIOLOGY | 2011年 / 21卷 / 01期
关键词：
Microarray gene signatures; Proliferation genes; Polo-like kinase 1 (PLK1); Epithelial cell adhesion molecule (EpCAM); Hepatic progenitors and cancer initiating/stem cells; Polycomb repressive complex 2 (PRC2); HEPATITIS-B-VIRUS; POLO-LIKE KINASES; X-PROTEIN; ALPHA-FETOPROTEIN; BETA-CATENIN; STEM-CELLS; EXPRESSION; POLYCOMB; CANCER; EPCAM;
D O I：
10.1016/j.semcancer.2010.09.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Primary hepatocellular carcinoma (HCC) is a significant human cancer globally, with poor prognosis. New and efficacious therapy strategies are needed as well as new biomarkers for early detection of at-risk patients. In this review, we discuss select microarray studies of human HCCs, and propose a gene signature that has promise for clinical/translational application. This gene signature combines the proliferation cluster of genes and the hepatic cancer initiating/stem cell gene cluster for identification of HCCs with poor prognosis. Evidence from cell-based assays identifies the existence of a mechanistic link between these two gene clusters, involving the proliferation cluster gene polo-like kinase 1 (PLK1). We propose that PLK1 is a promising therapy target for HCC. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4 / 9
页数：6
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