Comparison of antimicrobial susceptibility interpretation among Enterobacteriaceae using CLSI and EUCAST breakpoints

被引：6
作者：
Swathi, Suravaram [1 ]
Vivek, Hada [2 ]
Siddiqui, Imran Ahmed [3 ]
机构：
[1] ESIC Med Coll & Hosp, Dept Microbiol, Hyderabad, India
[2] All India Inst Med Sci, Dept Microbiol, Gorakhpur 273008, Uttar Pradesh, India
[3] ESIC Med Coll & Hosp, Dept Biochem, Hyderabad, India
来源：
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY | 2021年 / 39卷 / 03期
关键词：
CLSI; EUCAST; Antimicrobial susceptibility; Minimum inhibitory concentration; Breakpoints;
D O I：
10.1016/j.ijmmb.2021.05.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Purpose: To determine the difference in antimicrobial susceptibility of various antibiotics using the CLSI & EUCAST breakpoints. Methods: In this non interventional, retrospective observational study, we reviewed minimum inhibitory concentrations (MIC) of various antibiotics routinely reported for Enterobacteriaceae clinical isolates, from an automated microbiology identification system (VITEK-2). These MICs were then analysed using both CLSI 2019 and EUCAST 2019 guidelines and classified as per the breakpoints into various categories. Results: The concordance rates of the antimicrobial susceptibility for various drugs ranged from 78.2% to 100% among two breakpoints. Perfect agreement with kappa = 1 (p<0.001) was observed for only three antimicrobials ceftriaxone, levofloxacin and trimethoprim-sulfamethoxazole. The changes in antimicrobial susceptibility interpretation for cefepime, ciprofloxacin, amoxicillin clavulanic acid was majorly in Intermediate category. Conclusion: The change in interpretation of the susceptibility will lead to change in the usage of antibiotics especially due to recent change in definition of I by EUCAST. There is need of more studies in this aspect to ascertain clinical implication of change in antimicrobial susceptibility.
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收藏
页码：315 / 319
页数：5
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