A stochastic SIS epidemic with demography: initial stages and time to extinction

被引:13
作者
Andersson, Patrik [1 ]
Lindenstrand, David [1 ]
机构
[1] Stockholm Univ, Dept Math, S-10691 Stockholm, Sweden
关键词
Stochastic epidemic model; Quasi stationarity; SIS model; Coupling; Ornstein-Uhlenbeck; Diffusion approximation; Outbreak probability;
D O I
10.1007/s00285-010-0336-x
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We study an open population stochastic epidemic model from the time of introduction of the disease, through a possible outbreak and to extinction. The model describes an SIS (susceptible-infective-susceptible) epidemic where all individuals, including infectious ones, reproduce at a given rate. An approximate expression for the outbreak probability is derived using a coupling argument. Further, we analyse the behaviour of the model close to quasi-stationarity, and the time to disease extinction, with the aid of a diffusion approximation. In this situation the number of susceptibles and infectives behaves as an Ornstein-Uhlenbeck process, centred around the stationary point, for an exponentially distributed time before going extinct.
引用
收藏
页码:333 / 348
页数:16
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