Progress in the care of common inherited atherogenic disorders of apolipoprotein B metabolism

被引：30

作者：

Ellis, Katrina L. ^{[1
,2
,3
]}

Hooper, Amanda J. ^{[1
,4
,5
,6
]}

Burnett, John R. ^{[1
,4
,5
,7
]}

Watts, Gerald F. ^{[1
,7
]}

机构：

[1] Univ Western Australia, Sch Med & Pharmacol, POB X2213, Perth, WA 6847, Australia

[2] Univ Western Australia, Ctr Genet Origins Hlth & Dis, 35 Stirling Highway, Perth, WA 6009, Australia

[3] Curtin Univ, 35 Stirling Highway, Perth, WA 6009, Australia

[4] Royal Perth Hosp, PathWest Lab Med WA, Perth, WA, Australia

[5] Fiona Stanley Hosp Network, Perth, WA, Australia

[6] Univ Western Australia, Sch Pathol & Lab Med, 35 Stirling Highway, Perth, WA 6009, Australia

[7] Royal Perth Hosp, Dept Cardiol, Lipid Disorders Clin, Wellington St, Perth, WA, Australia

来源：

NATURE REVIEWS ENDOCRINOLOGY | 2016年 / 12卷 / 08期

关键词：

FAMILIAL-COMBINED HYPERLIPIDEMIA; DENSITY-LIPOPROTEIN RECEPTOR; CORONARY-ARTERY-DISEASE; SUBTILISIN/KEXIN TYPE 9; NON-HDL CHOLESTEROL; TRIAL ATHEROTHROMBOSIS INTERVENTION; AMERICAN-DIABETES-ASSOCIATION; TRANSFER PROTEIN INHIBITOR; LIPID-LOWERING THERAPY; LDL-CHOLESTEROL;

D O I：

10.1038/nrendo.2016.69

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Familial hypercholesterolaemia, familial combined hyperlipidaemia (FCH) and elevated lipoprotein(a) are common, inherited disorders of apolipoprotein B metabolism that markedly accelerate the onset of atherosclerotic cardiovascular disease (ASCVD). These disorders are frequently encountered in clinical lipidology and need to be accurately identified and treated in both index patients and their family members, to prevent the development of premature ASCVD. The optimal screening strategies depend on the patterns of heritability for each condition. Established therapies are widely used along with lifestyle interventions to regulate levels of circulating lipoproteins. New therapeutic strategies are becoming available, and could supplement traditional approaches in the most severe cases, but their long-term cost-effectiveness and safety have yet to be confirmed. We review contemporary developments in the understanding, detection and care of these highly atherogenic disorders of apolipoprotein B metabolism.

引用

页码：467 / 484

页数：18

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