Comparison of salivary nitric oxide and epidermal growth factor level between diabetic patients and healthy individuals

被引：9

作者：

Abdolsamadi, Hamid Reza ^{[1
]}

Rezaei, Fatemeh ^{[2
]}

Goodarzi, Mohammad Taghi ^{[3
]}

Moghimbeigi, Abbas ^{[4
]}

Jazaeri, Mina ^{[5
]}

Asadi, Soheila ^{[6
]}

Ahmadi-Motamayel, Fatemeh ^{[7
]}

机构：

[1] Hamadan Univ Med Sci, Sch Dent, Dent Res Ctr, Dept Oral Med, Hamadan, Iran

[2] Kermanshah Univ Med Sci, Sch Dent, Dept Oral Med, Kermanshah, Iran

[3] Hamadan Univ Med Sci, Sch Med, Res Ctr Mol Med, Hamadan, Iran

[4] Hamadan Univ Med Sci, Sch Publ Hlth, Dept Biostat, Hamadan, Iran

[5] Hamadan Univ Med Sci, Sch Dent, Dept Oral Med, Hamadan, Iran

[6] Hamadan Univ Med Sci, Sch Med, Dept Biochem, Hamadan, Iran

[7] Hamadan Univ Med Sci, Dent Sch, Dept Oral Med, Res Ctr Mol Med, Hamadan, Iran

来源：

INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES | 2015年 / 35卷

关键词：

Type; 1; diabetesmellitus; Type 2 diabetes mellitus; Biomarker;

D O I：

10.1007/s13410-014-0207-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The purpose of the current study was to compare salivary Nitric oxide and epidermal growth factor level in diabetic patients and healthy individuals. In this pairedcontrol study 20 patients with type 1 diabetes mellitus, 20 patients with type 2 diabetes mellitus and 20 age and sex matched healthy subjects participated. The level of salivary Nitric oxide was increased in type 1 and 2 diabetic patients in comparison to control individuals (P=0.037 and P=0.058), respectively. Epidermal growth factor concentration was higher in type 1 and 2 diabetic patients compare to healthy ones, (P=0.037 and P=0.005) respectively. There was no significant difference between salivary Nitric oxide and Epidermal growth factor level regarding to the type of diabetes (P>0.05). Significant statistical correlation was found between Nitric oxide and Epidermal growth factor levels and the fasting blood glucose and HbA1c (P<0.001). Conclusions: Salivary Nitric oxide and Epidermal growth factor levels were higher in type 1 and type 2 diabetic patients and there was correlation with severity of disease.

引用

页码：S477 / S482

页数：6

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