Obstructive sleep apnea in non-dialyzed chronic kidney disease patients: Association with body adiposity and sarcopenia

被引:12
作者
Rodrigues Fernandes, Julia Freitas [1 ]
Barreto Silva, Maria Ines [2 ]
Loivos, Claudio Pinheiro [1 ]
Medeiros Menna Barreto, Ana Paula [3 ]
Meira, Vagner da Silva [1 ]
Kaiser, Sergio Emanuel [4 ]
Bregman, Rachel [5 ]
Simas Torres Klein, Marcia Regina [2 ]
机构
[1] Univ Estado Rio De Janeiro, Post Grad Program Clin & Expt Pathophysiol, Rio De Janeiro, Brazil
[2] Univ Estado Rio De Janeiro, Nutr Inst, Dept Appl Nutr, Rio De Janeiro, Brazil
[3] Univ Estado Rio De Janeiro, Post Grad Program Med Sci, Rio De Janeiro, Brazil
[4] Univ Estado Rio De Janeiro, Discipline Clin & Expt Pathophysiol, Rio De Janeiro, Brazil
[5] Univ Estado Rio De Janeiro, Nephrol Div, Rio De Janeiro, Brazil
关键词
Obstructive sleep apnea; Chronic kidney disease; Obesity; Neck circumference; Sarcopenia; MUSCLE; PREVALENCE; OBESITY; RISK; EPIDEMIOLOGY; DIAGNOSIS; SEVERITY; STRENGTH; EVENTS; HEALTH;
D O I
10.1016/j.nut.2018.04.013
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Objectives: Obstructive sleep apnea (OSA) is a risk factor for cardiovascular disease (CVD), the main cause of mortality in chronic kidney disease (CKD). Although the prevalence of OSA in patients with CKD has not been established, a few studies suggest that it is higher than in the general population, potentially increasing the risk for CVD. Obesity increases the risk, whereas sarcopenia has been suggested as a consequence of OSA in the general population. To our knowledge, these associations have not been adequately evaluated in patients with CKD. The aim of this study was to evaluate OSA frequency and its association with total and upper body adiposity and sarcopenia in non-dialyzed CKD patients. Methods: This cross-sectional study included 73 patients with stages 3b-4 CKD (42 men, 62.9 +/- 1.1 y of age). Glomerular filtration rate was estimated by the CKD-Epidemiology Collaboration equation. Patients were assessed for OSA by Watch-PAT200 (apnea-hypopnea index >= 5 events hourly; Itamar Medical), total body adiposity by dual-energy x-ray absorptiometry (DXA) and body mass index (BMI), upper body adiposity by anthropometric parameters and by trunk and visceral fat by DXA, and sarcopenia. Results: OSA frequency was 67% (N = 49). Both total and upper body adiposity were associated with the presence and severity of OSA In non-obese patients (BMI <30 kg/m(2)), upper body obesity increased significantly the frequency of OSA. OSA association with sarcopenia was blunted when BMI was included in regression model. Conclusions: Results from the present study suggest that in non-dialyzed CKD patients OSA is very common and associated with total and upper body obesity, but not with sarcopenia. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码:282 / 289
页数:8
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