ONE-POT SYNTHESIS OF 2-SUBSTITUTED 3-THIOXO-2,3-DIHYDRO-1H-ISOINDOL-1-ONES BY THE REACTION OF N-SUBSTITUTED 2,N-DILITHIOBENZAMIDES WITH ISOTHIOCYANATES

被引：4
|
作者：
Kobayashi, Kazuhiro [1 ]
Fujiwara, Daiki [1 ]
机构：
[1] Tottori Univ, Grad Sch Sustainabil Sci, Dept Engn, Appl Chem Field,Chem & Biotechnol Course, 4-101 Koyama Minami, Tottori 6808552, Japan
来源：
HETEROCYCLES | 2017年 / 94卷 / 09期
关键词：
DERIVATIVES; ANTAGONISTS; DESIGN;
D O I：
10.3987/COM-17-13756
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This paper describes an efficient one-pot method for the preparation of 2-substituted 3-thioxo-1H-isoindol-l-ones (3-thioxoisoindolinones) by the reaction of N-substituted 2,N-dilithiobenzamides, generated by treating N-substituted benzamides with two equivalents of butyllithium, with the respective isothiocyanates followed by ring closure of the resulting N-alkyl(or aryl)-2-(alkyl(or aryl)thiocarbamoyl)benzamide derivatives with loss of alkyl(or aryl)amines.
引用
收藏
页码：1759 / 1765
页数：7
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