Bicarbonate refractory QRS prolongation and left bundle-branch block following escitalopram and lamotrigine overdose: A case report and literature review of toxic left bundle-branch block

被引：7

作者：

Farkas, A. N. ^{[1
]}

Marcott, M. ^{[2
]}

Yanta, J. H. ^{[1
]}

Pizon, A. F. ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Emergency Med, Div Med Toxicol, Pittsburgh, PA USA

[2] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA

来源：

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 2018年 / 43卷 / 05期

关键词：

cardiotoxicity; escitalopram; lamotrigine; left bundle-branch block; overdose; poisoning; BUPROPION; SEIZURES;

D O I：

10.1111/jcpt.12698

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

What is known and objectiveToxic prolongation of the QRS interval most often results from blockade of cardiac voltage-gated sodium channels and manifests on electrocardiogram with a right bundle-branch block-like morphology. Rarely, a left bundle-branch block (LBBB) morphology has been reported. Case reportWe report a case of transient LBBB resultant from ingestion of lamotrigine and citalopram which was refractory to sodium bicarbonate therapy and eventually resolved spontaneously. What is new and conclusionCases of toxic LBBB are less likely to respond to bicarbonate therapy, suggesting that this finding is due to a mechanism other than sodium channel blockade.

引用

页码：717 / 722

页数：6

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