A synthesis of the platelet aggregation inhibitor xemilofiban from L-aspartic acid. Confirmation of the absolute configuration.

被引：8

作者：

Boys, ML ^{[1
]}

机构：

[1] GD Searle & Co, Dept Chem Sci, Skokie, IL 60077 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(98)00602-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of xemilofiban (SC-54684A) from L-aspartic acid has been achieved in an overall yield of 18 %, and the absolute configuration has been confirmed, (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3449 / 3450

页数：2

共 7 条

[1]

BABIAK K, 1996, Patent No. 5536869

[2]

Corey E.J., 1972, TETRAHEDRON LETT, V13, P3769, DOI DOI 10.1016/S0040-4039(01)94157-7

[3] A very short, efficient and inexpensive synthesis of the prodrug form of SC-54701A - A platelet aggregation inhibitor [J].

Cossy, J ;

Schmitt, A ;

Cinquin, C ;

Buisson, D ;

Belotti, D .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (13) :1699-1700

[4] FORMATION OF AN OPTICALLY-ACTIVE ALPHA-AMINO ALDEHYDE IN THE BETA-LACTAM SERIES [J].

LABIA, R ;

MORIN, C .

CHEMISTRY LETTERS, 1984, (06) :1007-1008

[5]

OHKUBO M, Patent No. 9508536

[6]

Salzmann T. N., 1980, J AM CHEM SOC, V102, p[6163, 49]

[7] POTENT IN-VITRO AND IN-VIVO INHIBITORS OF PLATELET-AGGREGATION BASED UPON THE ARG-GLY-ASP SEQUENCE OF FIBRINOGEN - (AMINOBENZAMIDINO)SUCCINYL (ABAS) SERIES OF ORALLY-ACTIVE FIBRINOGEN RECEPTOR ANTAGONISTS [J].

ZABLOCKI, JA ;

RICO, JG ;

GARLAND, RB ;

ROGERS, TE ;

WILLIAMS, K ;

SCHRETZMAN, LA ;

RAO, SA ;

BOVY, PR ;

TJOENG, FS ;

LINDMARK, RJ ;

TOTH, MV ;

ZUPEC, ME ;

MCMACKINS, DE ;

ADAMS, SP ;

MIYANO, M ;

MARKOS, CS ;

MILTON, MN ;

PAULSON, S ;

HERIN, M ;

JACQMIN, P ;

NICHOLSON, NS ;

PANZERKNODLE, SG ;

HAAS, NF ;

PAGE, JD ;

SZALONY, JA ;

TAITE, BB ;

SALYERS, AK ;

KING, LW ;

CAMPION, JG ;

FEIGEN, LP .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (13) :2378-2394

← 1 →