Duplication of the leg - Renal agenesis: Congenital malformation syndrome

被引：11

作者：

Griffet, J ^{[1
]}

Bastiani-Griffet, F ^{[1
]}

Jund, S ^{[1
]}

Moreigne, M ^{[1
]}

Zabjek, KF ^{[1
]}

机构：

[1] Fac Med Nice, Dept Pediat Surg, F-06034 Nice, France

来源：

JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B | 2000年 / 9卷 / 04期

关键词：

caudal duplication; renal agenesis;

D O I：

10.1097/01202412-200010000-00015

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

A case is given of a male born with a duplication of the left leg and ipsilateral kidney agenesis. Although the etiology is unknown, we believe this association represents a congenital malformation syndrome. It is a polytopic developmental field defect. The growth factor IGF-I produced by the intermediary mesoderm or mesonephros (embryonary kidney) could be implicated in the induction limb development and the application of FGF-8 protein to the flank of young chick embryos inducing the development of additional limbs. It is possible that one or more of the growth factors produced by the mesonephros take some cells of the intermediary mesoderm out of their renal way to form a supernumerary limb.

引用

页码：306 / 308

页数：3

共 22 条

[1] DEVELOPMENTAL REGULATION OF INSULIN AND TYPE-I INSULIN-LIKE GROWTH-FACTOR RECEPTORS AND ABSENCE OF TYPE-II RECEPTORS IN CHICKEN-EMBRYO TISSUES [J].