Gut Microbiota, Inflammation, and Colorectal Cancer

被引：429

作者：

Brennan, Caitlin A. ^{[1
,2
]}

Garrett, Wendy S. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[2] Harvard TH Chan Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA

[3] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[4] Broad Inst Harvard & MIT, Canc Program, Cambridge, MA 02142 USA

[5] Harvard Med Sch, Dept Med, Boston, MA 02115 USA

来源：

ANNUAL REVIEW OF MICROBIOLOGY, VOL 70 | 2016年 / 70卷

关键词：

colorectal cancer; inflammation; colitis; mucosal immunology; microbiota/microbiome; Fusobacterium; REGULATORY T-CELLS; FUSOBACTERIUM-NUCLEATUM; INTESTINAL MICROBIOTA; MOLECULAR-FEATURES; EPITHELIAL-CELLS; GENE-EXPRESSION; IMMUNE CELLS; DNA-DAMAGE; IN-VIVO; TUMORIGENESIS;

D O I：

10.1146/annurev-micro-102215-095513

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Colorectal cancer is the second-leading cause of cancer-related deaths in the United States and fourth-leading cause of cancer-related deaths worldwide. While cancer is largely considered to be a disease of genetic and environmental factors, increasing evidence has demonstrated a role for the microbiota (the microorganisms associated with the human body) in shaping inflammatory environments and promoting tumor growth and spread. Herein, we discuss both human data from meta'omics analyses and data from mechanistic studies in cell culture and animal models that support specific bacterial agents as potentiators of tumorigenesis-including Fusobacterium nucleatum, enterotoxigenic Bacteroides fragilis, and colibactin-producing Escherichia coli. Further, we consider how microbes can be used in diagnosing colorectal cancer and manipulating the tumor environment to encourage better patient outcomes in response to immunotherapy treatments.

引用

页码：395 / 411

页数：17

共 98 条

[1] Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation [J].

Arpaia, Nicholas ;

Campbell, Clarissa ;

Fan, Xiying ;

Dikiy, Stanislav ;

van der Veeken, Joris ;

deRoos, Paul ;

Liu, Hui ;

Cross, Justin R. ;

Pfeffer, Klaus ;

Coffer, Paul J. ;

Rudensky, Alexander Y. .

NATURE, 2013, 504 (7480) :451-+

[2] Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota [J].

Arthur, Janelle C. ;

Perez-Chanona, Ernesto ;

Muehlbauer, Marcus ;

Tomkovich, Sarah ;

Uronis, Joshua M. ;

Fan, Ting-Jia ;

Campbell, Barry J. ;

Abujamel, Turki ;

Dogan, Belgin ;

Rogers, Arlin B. ;

Rhodes, Jonathan M. ;

Stintzi, Alain ;

Simpson, Kenneth W. ;

Hansen, Jonathan J. ;

Keku, Temitope O. ;

Fodor, Anthony A. ;

Jobin, Christian .

SCIENCE, 2012, 338 (6103) :120-123

[3] Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells [J].

Atarashi, Koji ;

Tanoue, Takeshi ;

Ando, Minoru ;

Kamada, Nobuhiko ;

Nagano, Yuji ;

Narushima, Seiko ;

Suda, Wataru ;

Imaoka, Akemi ;

Setoyama, Hiromi ;

Nagamori, Takashi ;

Ishikawa, Eiji ;

Shima, Tatsuichiro ;

Hara, Taeko ;

Kado, Shoichi ;

Jinnohara, Toshi ;

Ohno, Hiroshi ;

Kondo, Takashi ;

Toyooka, Kiminori ;

Watanabe, Eiichiro ;

Yokoyama, Shin-ichiro ;

Tokoro, Shunji ;

Mori, Hiroshi ;

Noguchi, Yurika ;

Morita, Hidetoshi ;

Ivanov, Ivaylo I. ;

Sugiyama, Tsuyoshi ;

Nunez, Gabriel ;

Camp, J. Gray ;

Hattori, Masahira ;

Umesaki, Yoshinori ;

Honda, Kenya .

CELL, 2015, 163 (02) :367-380

[4] Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species [J].

Atarashi, Koji ;

Tanoue, Takeshi ;

Shima, Tatsuichiro ;

Imaoka, Akemi ;

Kuwahara, Tomomi ;

Momose, Yoshika ;

Cheng, Genhong ;

Yamasaki, Sho ;

Saito, Takashi ;

Ohba, Yusuke ;

Taniguchi, Tadatsugu ;

Takeda, Kiyoshi ;

Hori, Shohei ;

Ivanov, Ivaylo I. ;

Umesaki, Yoshinori ;

Itoh, Kikuji ;

Honda, Kenya .

SCIENCE, 2011, 331 (6015) :337-341

[5] Host lysozyme-mediated lysis of Lactococcus lactis facilitates delivery of colitis-attenuating superoxide dismutase to inflamed colons [J].

Ballal, Sonia A. ;

Veiga, Patrick ;

Fenn, Kathrin ;

Michaud, Monia ;

Kim, Jason H. ;

Gallini, Carey Ann ;

Glickman, Jonathan N. ;

Quere, Gaelle ;

Garault, Peggy ;

Beal, Chloe ;

Derrien, Muriel ;

Courtin, Pascal ;

Kulakauskas, Saulius ;

Chapot-Chartier, Marie-Pierre ;

Vlieg, Johan van Hylckama ;

Garrett, Wendy S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (25) :7803-7808

[6] Cancers Complicating Inflammatory Bowel Disease [J].

Beaugerie, Laurent ;

Itzkowitz, Steven H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (15) :1441-1452

[7] REGULATION OF TUMOR NECROSIS FACTOR GENE-EXPRESSION IN COLORECTAL ADENOCARCINOMA - INVIVO ANALYSIS BY INSITU HYBRIDIZATION [J].

BEISSERT, S ;

BERGHOLZ, M ;

WAASE, I ;

LEPSIEN, G ;

SCHAUER, A ;

PFIZENMAIER, K ;

KRONKE, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (13) :5064-5068

[8] Gut Microbial Metabolism Drives Transformation of Msh2-Deficient Colon Epithelial Cells [J].

Belcheva, Antoaneta ;

Irrazabal, Thergiory ;

Robertson, Susan J. ;

Streutker, Catherine ;

Maughan, Heather ;

Rubino, Stephen ;

Moriyama, Eduardo H. ;

Copeland, Julia K. ;

Kumar, Sachin ;

Green, Blerta ;

Geddes, Kaoru ;

Pezo, Rossanna C. ;

Navarre, William W. ;

Milosevic, Michael ;

Wilson, Brian C. ;

Girardin, Stephen E. ;

Wolever, Thomas M. S. ;

Edelmann, Winfried ;

Guttman, David S. ;

Philpott, Dana J. ;

Martin, Alberto .

CELL, 2014, 158 (02) :288-299

[9] Role of the Microbiota in Immunity and Inflammation [J].

Belkaid, Yasmine ;

Hand, Timothy W. .

CELL, 2014, 157 (01) :121-141

[10] The Bacteroides fragilis Toxin Gene Is Prevalent in the Colon Mucosa of Colorectal Cancer Patients [J].

Boleij, Annemarie ;

Hechenbleikner, Elizabeth M. ;

Goodwin, Andrew C. ;

Badani, Ruchi ;

Stein, Ellen M. ;

Lazarev, Mark G. ;

Ellis, Brandon ;

Carroll, Karen C. ;

Albesiano, Emilia ;

Wick, Elizabeth C. ;

Platz, Elizabeth A. ;

Pardoll, Drew M. ;

Sears, Cynthia L. .

CLINICAL INFECTIOUS DISEASES, 2015, 60 (02) :208-215

← 1 2 3 4 5 6 7 8 9 10 →