Three new alkaloids and a new iridoid glycoside from the roots of Rehmannia glutinosa

被引：11

作者：

Li, Meng ^{[1
,2
]}

Wang, Xiaolan ^{[1
,2
]}

Zhang, Zhiguang ^{[1
,2
]}

Zhang, Jingke ^{[1
,2
]}

Zhao, Xuan ^{[1
,2
]}

Zheng, Xiaoke ^{[1
,2
]}

Feng, Weisheng ^{[1
,2
]}

机构：

[1] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Henan, Peoples R China

[2] Collaborat Innovat Ctr Resp Dis Diag & Treatment, Zhengzhou 450046, Henan, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2017年 / 21卷

基金：

“十二五”国家科技支撑计划重点项目”;

关键词：

Rehmannia glutinosa; Roots; Alkaloids; Iridoid glycosides; The protective effects of cardiomyocytes; IONONE GLYCOSIDES; RADIX; BARK; RATS;

D O I：

10.1016/j.phytol.2017.06.010

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new alkaloids, rehmanalkaloid A-C (1-3), and a new iridoid glycoside, rehmaglutoside L (4), together with nine known compounds, including (8S)-7,8-dihydrogeniposid (5), diglycoside (6), monomelittoside (7), mussaenoside (8), darendoside A (9), syringing (10), phenyl-6-O-beta-D-xylopyranosyl-O-beta-D-glucopyranoside (11), (7R, 8S)-4,9-dihydroxy-3,3'-dimethoxy-7,8-dihydrobenzofuran-1'-propanalneolignan (12), and trans-liovil (13), were isolated from a 95% EtOH extract of dried roots from Rehmannia glutinosa. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, and 1D and 2D NMR) analyses. Additionally, compounds 4-8 (iridoid glycosides) were evaluated for their protective effects on H714444444444444444444466666666669c2 cardiocytes impaired by doxorubicin. Among them, compounds 4-8 exhibited protective effects against DOX-induced cardiotoxicity.

引用

页码：157 / 162

页数：6

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