Three new alkaloids and a new iridoid glycoside from the roots of Rehmannia glutinosa

被引：11
作者：
Li, Meng [1 ,2 ]
Wang, Xiaolan [1 ,2 ]
Zhang, Zhiguang [1 ,2 ]
Zhang, Jingke [1 ,2 ]
Zhao, Xuan [1 ,2 ]
Zheng, Xiaoke [1 ,2 ]
Feng, Weisheng [1 ,2 ]
机构：
[1] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Henan, Peoples R China
[2] Collaborat Innovat Ctr Resp Dis Diag & Treatment, Zhengzhou 450046, Henan, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2017年 / 21卷
基金：
“十二五”国家科技支撑计划重点项目”;
关键词：
Rehmannia glutinosa; Roots; Alkaloids; Iridoid glycosides; The protective effects of cardiomyocytes; IONONE GLYCOSIDES; RADIX; BARK; RATS;
D O I：
10.1016/j.phytol.2017.06.010
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Three new alkaloids, rehmanalkaloid A-C (1-3), and a new iridoid glycoside, rehmaglutoside L (4), together with nine known compounds, including (8S)-7,8-dihydrogeniposid (5), diglycoside (6), monomelittoside (7), mussaenoside (8), darendoside A (9), syringing (10), phenyl-6-O-beta-D-xylopyranosyl-O-beta-D-glucopyranoside (11), (7R, 8S)-4,9-dihydroxy-3,3'-dimethoxy-7,8-dihydrobenzofuran-1'-propanalneolignan (12), and trans-liovil (13), were isolated from a 95% EtOH extract of dried roots from Rehmannia glutinosa. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, and 1D and 2D NMR) analyses. Additionally, compounds 4-8 (iridoid glycosides) were evaluated for their protective effects on H714444444444444444444466666666669c2 cardiocytes impaired by doxorubicin. Among them, compounds 4-8 exhibited protective effects against DOX-induced cardiotoxicity.
引用
收藏
页码：157 / 162
页数：6
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