A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population

被引：144

作者：

Shiraishi, Kouya ^{[1
]}

Kunitoh, Hideo ^{[2
]}

Daigo, Yataro ^{[3
,4
]}

Takahashi, Atsushi ^{[5
]}

Goto, Koichi ^{[6
]}

Sakamoto, Hiromi ^{[7
]}

Ohnami, Sumiko ^{[7
]}

Shimada, Yoko ^{[1
]}

Ashikawa, Kyota ^{[8
]}

Saito, Akira ^{[9
]}

Watanabe, Shun-ichi ^{[10
]}

Tsuta, Koji ^{[11
]}

Kamatani, Naoyuki ^{[5
]}

Yoshida, Teruhiko ^{[7
]}

Nakamura, Yusuke ^{[4
]}

Yokota, Jun ^{[12
]}

Kubo, Michiaki ^{[8
]}

Kohno, Takashi ^{[1
]}

机构：

[1] Natl Canc Ctr, Res Inst, Div Genome Biol, Tokyo 104, Japan

[2] Natl Canc Ctr, Div Thorac Oncol, Tokyo, Japan

[3] Shiga Univ Med Sci, Dept Med Oncol, Shiga, Japan

[4] Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome, Tokyo, Japan

[5] RIKEN, Ctr Genom Med, Lab Stat Anal, Kanagawa, Japan

[6] Natl Canc Ctr Hosp E, Thorac Oncol Div, Chiba, Japan

[7] Natl Canc Ctr, Res Inst, Div Genet, Tokyo 104, Japan

[8] RIKEN, Ctr Genom Med, Lab Genotyping Dev, Kanagawa, Japan

[9] StaGen Co Ltd, Stat Genet Anal Div, Tokyo, Japan

[10] Natl Canc Ctr, Div Thorac Surg, Tokyo, Japan

[11] Natl Canc Ctr, Div Pathol & Clin Labs, Tokyo, Japan

[12] Natl Canc Ctr, Res Inst, Div Multistep Carcinogenesis, Tokyo 104, Japan

来源：

NATURE GENETICS | 2012年 / 44卷 / 08期

基金：

日本学术振兴会;

关键词：

ULCERATIVE-COLITIS; NEVER SMOKERS; CANCER RISK; GENOTYPES; STRATIFICATION; VARIANTS; 5P15.33; IMPACT; SCAN; TP63;

D O I：

10.1038/ng.2353

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P-combined = 2.8 x 10(-40), odds ratio (OR) = 1.41) and 3q28 (rs10937405, P-combined = 6.9 x 10(-17), OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P-combined = 7.4 x 10(-11), OR = 1.20) and 6p21.3 (rs3817963, P-combined = 2.7 x 10(-10), OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.

引用

页码：900 / +

页数：5

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Bradfield, Jonathan P.
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Freeman, Colin
Giardina, Emiliano
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Kirby, Brian
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Mathew, Christopher G.
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McManus, Ross
Moessner, Rotraut
Moutsianas, Loukas
Naluai, Asa T.
Nestle, Frank O.
Novelli, Giuseppe
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Palmer, Colin N. A.
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[J]. NATURE GENETICS, 2010, 42 (11) : 985 - U106
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Hamajima, Nobuyuki
Kubo, Michiaki
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Yin, Zhihua
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Jin, Li
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Zhou, Baosen
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Wu, Tangchun
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Shen, Hongbing
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Real, Francisco X.
Van den Berg, David
Matullo, Giuseppe
Baris, Dalsu
Thun, Michael
Kiemeney, Lambertus A.
Vineis, Paolo
De Vivo, Immaculata
Albanes, Demetrius
Purdue, Mark P.
Rafnar, Thorunn
Hildebrandt, Michelle A. T.
Kiltie, Anne E.
Cussenot, Olivier
Golka, Klaus
Kumar, Rajiv
Taylor, Jack A.
Mayordomo, Jose I.
Jacobs, Kevin B.
Kogevinas, Manolis
Hutchinson, Amy
Wang, Zhaoming
Fu, Yi-Ping
Prokunina-Olsson, Ludmila
Burdett, Laurie
Yeager, Meredith
Wheeler, William
Tardon, Adonina
Serra, Consol
Carrato, Alfredo
Garcia-Closas, Reina
Lloreta, Josep
Johnson, Alison
Schwenn, Molly
Karagas, Margaret R.
Schned, Alan
Andriole, Gerald, Jr.
Grubb, Robert, III
Black, Amanda
Jacobs, Eric J.
Diver, W. Ryan
Gapstur, Susan M.
Weinstein, Stephanie J.
Virtamo, Jarmo
[J]. NATURE GENETICS, 2010, 42 (11) : 978 - U98
[46] Association of New Loci Identified in European Genome-Wide Association Studies with Susceptibility to Type 2 Diabetes in the Japanese
Ohshige, Toshihiko
Iwata, Minoru
Omori, Shintaro
Tanaka, Yasushi
Hirose, Hiroshi
Kaku, Kohei
Maegawa, Hiroshi
Watada, Hirotaka
Kashiwagi, Atsunori
Kawamori, Ryuzo
Tobe, Kazuyuki
Kadowaki, Takashi
Nakamura, Yusuke
Maeda, Shiro
[J]. PLOS ONE, 2011, 6 (10):
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Jiang, Guoliang
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Cao, Guangwen
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Zhou, Yongjian
Zuo, Chaohui
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Chen, Shih-Pin
Fuh, Jong-Ling
Chung, Ming-Yi
Lin, Ying-Chao
Liao, Yi-Chu
Wang, Yen-Feng
Hsu, Chia-Lin
Yang, Ueng-Cheng
Lin, Ming-Wei
Chiou, Jen-Jie
Wang, Po-Jen
Chen, Ping-Kun
Fan, Pi-Chuan
Wu, Jer-Yuan
Chen, Yuan-Tsong
Kao, Lung-Sen
Fann, Cathy Shen-Jang
Wang, Shuu-Jiun
[J]. CEPHALALGIA, 2018, 38 (03) : 466 - 475
[49] Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region
Skibola, Christine F.
Berndt, Sonja I.
Vijai, Joseph
Conde, Lucia
Wang, Zhaoming
Yeager, Meredith
de Bakker, Paul I. W.
Birmann, Brenda M.
Vajdic, Claire M.
Foo, Jia-Nee
Bracci, Paige M.
Vermeulen, Roel C. H.
Slager, Susan L.
de Sanjose, Silvia
Wang, Sophia S.
Linet, Martha S.
Salles, Gilles
Lan, Qing
Severi, Gianluca
Hjalgrim, Henrik
Lightfoot, Tracy
Melbye, Mads
Gu, Jian
Ghesquieres, Herve
Link, Brian K.
Morton, Lindsay M.
Holly, Elizabeth A.
Smith, Alex
Tinker, Lesley F.
Teras, Lauren R.
Kricker, Anne
Becker, Nikolaus
Purdue, Mark P.
Spinelli, John J.
Zhang, Yawei
Giles, Graham G.
Vineis, Paolo
Monnereau, Alain
Bertrand, Kimberly A.
Albanes, Demetrius
Zeleniuch-Jacquotte, Anne
Gabbas, Attilio
Chung, Charles C.
Burdett, Laurie
Hutchinson, Amy
Lawrence, Charles
Montalvan, Rebecca
Liang, Liming
Huang, Jinyan
Ma, Baoshan
[J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2014, 95 (04) : 462 - 471
[50] Genome-wide Association Study Identifies TNFSF15 and POU2AF1 as Susceptibility Loci for Primary Biliary Cirrhosis in the Japanese Population
Nakamura, Minoru
Nishida, Nao
Kawashima, Minae
Aiba, Yoshihiro
Tanaka, Atsushi
Yasunami, Michio
Nakamura, Hitomi
Komori, Atsumasai
Nakamuta, Makoto
Zeniya, Mikio
Hashimoto, Etsuko
Ohira, Hiromasa
Yamamoto, Kazuhide
Onji, Morikazu
Kaneko, Shuichi
Honda, Masao
Yamagiwa, Satoshi
Nakao, Kazuhiko
Ichida, Takafumi
Takikawa, Hajime
Seike, Masataka
Umemura, Takeji
Ueno, Yoshiyuki
Sakisaka, Shotaro
Kikuchi, Kentaro
Ebinuma, Hirotoshi
Yamashiki, Noriyo
Tamura, Sumito
Sugawara, Yasuhiko
Mori, Akira
Yagi, Shintaro
Shirabe, Ken
Taketomi, Akinobu
Arai, Kuniaki
Monoe, Kyoko
Ichikawa, Tatsuki
Taniai, Makiko
Miyake, Yasuhiro
Kumagi, Teru
Abe, Masanori
Yoshizawa, Kaname
Joshita, Satoru
Shimoda, Shinji
Honda, Koichi
Takahashi, Hiroki
Hirano, Katsuji
Takeyama, Yasuaki
Harada, Kenichi
Migita, Kiyoshi
Ito, Masahiro
[J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2012, 91 (04) : 721 - 728

← 1 2 3 4 5 →