A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population

被引：144

作者：

Shiraishi, Kouya ^{[1
]}

Kunitoh, Hideo ^{[2
]}

Daigo, Yataro ^{[3
,4
]}

Takahashi, Atsushi ^{[5
]}

Goto, Koichi ^{[6
]}

Sakamoto, Hiromi ^{[7
]}

Ohnami, Sumiko ^{[7
]}

Shimada, Yoko ^{[1
]}

Ashikawa, Kyota ^{[8
]}

Saito, Akira ^{[9
]}

Watanabe, Shun-ichi ^{[10
]}

Tsuta, Koji ^{[11
]}

Kamatani, Naoyuki ^{[5
]}

Yoshida, Teruhiko ^{[7
]}

Nakamura, Yusuke ^{[4
]}

Yokota, Jun ^{[12
]}

Kubo, Michiaki ^{[8
]}

Kohno, Takashi ^{[1
]}

机构：

[1] Natl Canc Ctr, Res Inst, Div Genome Biol, Tokyo 104, Japan

[2] Natl Canc Ctr, Div Thorac Oncol, Tokyo, Japan

[3] Shiga Univ Med Sci, Dept Med Oncol, Shiga, Japan

[4] Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome, Tokyo, Japan

[5] RIKEN, Ctr Genom Med, Lab Stat Anal, Kanagawa, Japan

[6] Natl Canc Ctr Hosp E, Thorac Oncol Div, Chiba, Japan

[7] Natl Canc Ctr, Res Inst, Div Genet, Tokyo 104, Japan

[8] RIKEN, Ctr Genom Med, Lab Genotyping Dev, Kanagawa, Japan

[9] StaGen Co Ltd, Stat Genet Anal Div, Tokyo, Japan

[10] Natl Canc Ctr, Div Thorac Surg, Tokyo, Japan

[11] Natl Canc Ctr, Div Pathol & Clin Labs, Tokyo, Japan

[12] Natl Canc Ctr, Res Inst, Div Multistep Carcinogenesis, Tokyo 104, Japan

来源：

NATURE GENETICS | 2012年 / 44卷 / 08期

基金：

日本学术振兴会;

关键词：

ULCERATIVE-COLITIS; NEVER SMOKERS; CANCER RISK; GENOTYPES; STRATIFICATION; VARIANTS; 5P15.33; IMPACT; SCAN; TP63;

D O I：

10.1038/ng.2353

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P-combined = 2.8 x 10(-40), odds ratio (OR) = 1.41) and 3q28 (rs10937405, P-combined = 6.9 x 10(-17), OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P-combined = 7.4 x 10(-11), OR = 1.20) and 6p21.3 (rs3817963, P-combined = 2.7 x 10(-10), OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.

引用

页码：900 / +

页数：5

共 50 条

[31] Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia
Lan, Qing
Hsiung, Chao A.
Matsuo, Keitaro
Hong, Yun-Chul
Seow, Adeline
Wang, Zhaoming
Hosgood, H. Dean, III
Chen, Kexin
Wang, Jiu-Cun
Chatterjee, Nilanjan
Hu, Wei
Wong, Maria Pik
Zheng, Wei
Caporaso, Neil
Park, Jae Yong
Chen, Chien-Jen
Kim, Yeul Hong
Kim, Young Tae
Landi, Maria Teresa
Shen, Hongbing
Lawrence, Charles
Burdett, Laurie
Yeager, Meredith
Yuenger, Jeffrey
Jacobs, Kevin B.
Chang, I-Shou
Mitsudomi, Tetsuya
Kim, Hee Nam
Chang, Gee-Chen
Bassig, Bryan A.
Tucker, Margaret
Wei, Fusheng
Yin, Zhihua
Wu, Chen
An, She-Juan
Qian, Biyun
Lee, Victor Ho Fun
Lu, Daru
Liu, Jianjun
Jeon, Hyo-Sung
Hsiao, Chin-Fu
Sung, Jae Sook
Kim, Jin Hee
Gao, Yu-Tang
Tsai, Ying-Huang
Jung, Yoo Jin
Guo, Huan
Hu, Zhibin
Hutchinson, Amy
Wang, Wen-Chang
NATURE GENETICS, 2012, 44 (12) : 1330 - 1335
[32] Genome-wide association identifies three new susceptibility loci for Paget's disease of bone
Albagha, Omar M. E.
Wani, Sachin E.
Visconti, Micaela R.
Alonso, Nerea
Goodman, Kirsteen
Brandi, Maria Luisa
Cundy, Tim
Chung, Pui Yan Jenny
Dargie, Rosemary
Devogelaer, Jean-Pierre
Falchetti, Alberto
Fraser, William D.
Gennari, Luigi
Gianfrancesco, Fernando
Hooper, Michael J.
Van Hul, Wim
Isaia, Gianluca
Nicholson, Geoff C.
Nuti, Ranuccio
Papapoulos, Socrates
del Pino Montes, Javier
Ratajczak, Thomas
Rea, Sarah L.
Rendina, Domenico
Gonzalez-Sarmiento, Rogelio
Di Stefano, Marco
Ward, Lynley C.
Walsh, John P.
Ralston, Stuart H.
NATURE GENETICS, 2011, 43 (07) : 685 - U104
[33] Genome-wide association study identifies genetic risk loci for adiposity in a Taiwanese population
Wong, Henry Sung-Ching
Tsai, Szu-Yi
Chu, Hou-Wei
Lin, Min-Rou
Lin, Gan-Hong
Tai, Yu-Ting
Shen, Chen-Yang
Chang, Wei-Chiao
PLOS GENETICS, 2022, 18 (01):
[34] Genome-Wide Association Study in East Asians Identifies Novel Susceptibility Loci for Breast Cancer
Long, Jirong
Cai, Qiuyin
Sung, Hyuna
Shi, Jiajun
Zhang, Ben
Choi, Ji-Yeob
Wen, Wanqing
Delahanty, Ryan J.
Lu, Wei
Gao, Yu-Tang
Shen, Hongbing
Park, Sue K.
Chen, Kexin
Shen, Chen-Yang
Ren, Zefang
Haiman, Christopher A.
Matsuo, Keitaro
Kim, Mi Kyung
Khoo, Ui Soon
Iwasaki, Motoki
Zheng, Ying
Xiang, Yong-Bing
Gu, Kai
Rothman, Nathaniel
Wang, Wenjing
Hu, Zhibin
Liu, Yao
Yoo, Keun-Young
Noh, Dong-Young
Han, Bok-Ghee
Lee, Min Hyuk
Zheng, Hong
Zhang, Lina
Wu, Pei-Ei
Shieh, Ya-Lan
Chan, Sum Yin
Wang, Shenming
Xie, Xiaoming
Kim, Sung-Won
Henderson, Brian E.
Le Marchand, Loic
Ito, Hidemi
Kasuga, Yoshio
Ahn, Sei-Hyun
Kang, Han Sung
Chan, Kelvin Y. K.
Iwata, Hiroji
Tsugane, Shoichiro
Li, Chun
Shu, Xiao-Ou
PLOS GENETICS, 2012, 8 (02)
[35] Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma
Chahal, Harvind S.
Lin, Yuan
Ransohoff, Katherine J.
Hinds, David A.
Wu, Wenting
Dai, Hong-Ji
Qureshi, Abrar A.
Li, Wen-Qing
Kraft, Peter
Tang, Jean Y.
Han, Jiali
Sarin, Kavita Y.
NATURE COMMUNICATIONS, 2016, 7
[36] Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci
Reveille, John D.
Sims, Anne-Marie
Danoy, Patrick
Evans, David M.
Leo, Paul
Pointon, Jennifer J.
Jin, Rui
Zhou, Xiaodong
Bradbury, Linda A.
Appleton, Louise H.
Davis, John C.
Diekman, Laura
Doan, Tracey
Dowling, Alison
Duan, Ran
Duncan, Emma L.
Farrar, Claire
Hadler, Johanna
Harvey, David
Karaderi, Tugce
Mogg, Rebecca
Pomeroy, Emma
Pryce, Karena
Taylor, Jacqueline
Savage, Laurie
Deloukas, Panos
Kumanduri, Vasudev
Peltonen, Leena
Ring, Sue M.
Whittaker, Pamela
Glazov, Evgeny
Thomas, Gethin P.
Maksymowych, Walter P.
Inman, Robert D.
Ward, Michael M.
Stone, Millicent A.
Weisman, Michael H.
Wordsworth, B. Paul
Brown, Matthew A.
NATURE GENETICS, 2010, 42 (02) : 123 - U47
[37] A next generation sequencing combined genome-wide association study identifies novel tuberculosis susceptibility loci in Chinese population
Li, Mo
Hu, Yi
Zhao, Baihui
Chen, Luan
Huang, Hailiang
Huai, Cong
Zhang, Xiaoqing
Zhang, Jinghong
Zhou, Wei
Shen, Lu
Zhen, Qi
Li, Bao
Wang, Wenjun
He, Lin
Qin, Shengying
GENOMICS, 2021, 113 (04) : 2377 - 2384
[38] A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia
Kim, Dong Hwan
Lee, Seung-Tae
Won, Hong-Hee
Kim, Seonwoo
Kim, Min-Ji
Kim, Hee-Jin
Kim, Sun-Hee
Kim, Jong-Won
Kim, Hyeoung-Joon
Kim, Yeo-Kyeoung
Sohn, Sang Kyun
Moon, Joon Ho
Jung, Chul Won
Lipton, Jeffrey H.
BLOOD, 2011, 117 (25) : 6906 - 6911
[39] Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese
Zheng, Ruijuan
Li, Zhiqiang
He, Fusheng
Liu, Haipeng
Chen, Jianhua
Chen, Jiayu
Xie, Xuefeng
Zhou, Juan
Chen, Hao
Wu, Xiangyang
Wu, Juehui
Chen, Boyu
Liu, Yahui
Cui, Haiyan
Fan, Lin
Sha, Wei
Liu, Yin
Wang, Jiqiang
Huang, Xiaochen
Zhang, Linfeng
Xu, Feifan
Wang, Jie
Feng, Yonghong
Qin, Lianhua
Yang, Hua
Liu, Zhonghua
Cui, Zhenglin
Liu, Feng
Chen, Xinchun
Gao, Shaorong
Sun, Silong
Shi, Yongyong
Ge, Baoxue
NATURE COMMUNICATIONS, 2018, 9
[40] Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers
Tonomura, Noriko
Elvers, Ingegerd
Thomas, Rachael
Megquier, Kate
Turner-Maier, Jason
Howald, Cedric
Sarver, Aaron L.
Swofford, Ross
Frantz, Aric M.
Ito, Daisuke
Mauceli, Evan
Arendt, Maja
Noh, Hyun Ji
Koltookian, Michele
Biagi, Tara
Fryc, Sarah
Williams, Christina
Avery, Anne C.
Kim, Jong-Hyuk
Barber, Lisa
Burgess, Kristine
Lander, Eric S.
Karlsson, Elinor K.
Azuma, Chieko
Modiano, Jaime F.
Breen, Matthew
Lindblad-Toh, Kerstin
PLOS GENETICS, 2015, 11 (02): : 1 - 24

← 1 2 3 4 5 →