A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population

被引：144

作者：

Shiraishi, Kouya ^{[1
]}

Kunitoh, Hideo ^{[2
]}

Daigo, Yataro ^{[3
,4
]}

Takahashi, Atsushi ^{[5
]}

Goto, Koichi ^{[6
]}

Sakamoto, Hiromi ^{[7
]}

Ohnami, Sumiko ^{[7
]}

Shimada, Yoko ^{[1
]}

Ashikawa, Kyota ^{[8
]}

Saito, Akira ^{[9
]}

Watanabe, Shun-ichi ^{[10
]}

Tsuta, Koji ^{[11
]}

Kamatani, Naoyuki ^{[5
]}

Yoshida, Teruhiko ^{[7
]}

Nakamura, Yusuke ^{[4
]}

Yokota, Jun ^{[12
]}

Kubo, Michiaki ^{[8
]}

Kohno, Takashi ^{[1
]}

机构：

[1] Natl Canc Ctr, Res Inst, Div Genome Biol, Tokyo 104, Japan

[2] Natl Canc Ctr, Div Thorac Oncol, Tokyo, Japan

[3] Shiga Univ Med Sci, Dept Med Oncol, Shiga, Japan

[4] Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome, Tokyo, Japan

[5] RIKEN, Ctr Genom Med, Lab Stat Anal, Kanagawa, Japan

[6] Natl Canc Ctr Hosp E, Thorac Oncol Div, Chiba, Japan

[7] Natl Canc Ctr, Res Inst, Div Genet, Tokyo 104, Japan

[8] RIKEN, Ctr Genom Med, Lab Genotyping Dev, Kanagawa, Japan

[9] StaGen Co Ltd, Stat Genet Anal Div, Tokyo, Japan

[10] Natl Canc Ctr, Div Thorac Surg, Tokyo, Japan

[11] Natl Canc Ctr, Div Pathol & Clin Labs, Tokyo, Japan

[12] Natl Canc Ctr, Res Inst, Div Multistep Carcinogenesis, Tokyo 104, Japan

来源：

NATURE GENETICS | 2012年 / 44卷 / 08期

基金：

日本学术振兴会;

关键词：

ULCERATIVE-COLITIS; NEVER SMOKERS; CANCER RISK; GENOTYPES; STRATIFICATION; VARIANTS; 5P15.33; IMPACT; SCAN; TP63;

D O I：

10.1038/ng.2353

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P-combined = 2.8 x 10(-40), odds ratio (OR) = 1.41) and 3q28 (rs10937405, P-combined = 6.9 x 10(-17), OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P-combined = 7.4 x 10(-11), OR = 1.20) and 6p21.3 (rs3817963, P-combined = 2.7 x 10(-10), OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.

引用

页码：900 / +

页数：5

共 50 条

[21] Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
Mitchell, Jonathan S.
Li, Ni
Weinhold, Niels
Foersti, Asta
Ali, Mina
van Duin, Mark
Thorleifsson, Gudmar
Johnson, David C.
Chen, Bowang
Halvarsson, Britt-Marie
Gudbjartsson, Daniel F.
Kuiper, Rowan
Stephens, Owen W.
Bertsch, Uta
Broderick, Peter
Campo, Chiara
Einsele, Hermann
Gregory, Walter A.
Gullberg, Urban
Henrion, Marc
Hillengass, Jens
Hoffmann, Per
Jackson, Graham H.
Johnsson, Ellinor
Joud, Magnus
Kristinsson, Sigurjdur Y.
Lenhoff, Stig
Lenive, Oleg
Mellqvist, Ulf-Henrik
Migliorini, Gabriele
Nahi, Hareth
Nelander, Sven
Nickel, Jolanta
Noethen, Markus M.
Rafnar, Thorunn
Ross, Fiona M.
da Silva Filho, Miguel Inacio
Swaminathan, Bhairavi
Thomsen, Hauke
Turesson, Ingemar
Vangsted, Annette
Vogel, Ulla
Waage, Anders
Walker, Brian A.
Wihlborg, Anna-Karin
Broyl, Annemiek
Davies, Faith E.
Thorsteinsdottir, Unnur
Langer, Christian
Hansson, Markus
NATURE COMMUNICATIONS, 2016, 7
[22] Genome-wide association study identifies multiple susceptibility loci for craniofacial microsomia
Zhang, Yong-Biao
Hu, Jintian
Zhang, Jiao
Zhou, Xu
Li, Xin
Gu, Chaohao
Liu, Tun
Xie, Yangchun
Liu, Jiqiang
Gu, Mingliang
Wang, Panpan
Wu, Tingting
Qian, Jin
Wang, Yue
Dong, Xiaoqun
Yu, Jun
Zhang, Qingguo
NATURE COMMUNICATIONS, 2016, 7
[23] Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis
Fingerlin, Tasha E.
Murphy, Elissa
Zhang, Weiming
Peljto, Anna L.
Brown, Kevin K.
Steele, Mark P.
Loyd, James E.
Cosgrove, Gregory P.
Lynch, David
Groshong, Steve
Collard, Harold R.
Wolters, Paul J.
Bradford, Williamson Z.
Kossen, Karl
Seiwert, Scott D.
du Bois, Roland M.
Garcia, Christine Kim
Devine, Megan S.
Gudmundsson, Gunnar
Isaksson, Helgi J.
Kaminski, Naftali
Zhang, Yingze
Gibson, Kevin F.
Lancaster, Lisa H.
Cogan, Joy D.
Mason, Wendi R.
Maher, Toby M.
Molyneaux, Philip L.
Wells, Athol U.
Moffatt, Miriam F.
Selman, Moises
Pardo, Annie
Kim, Dong Soon
Crapo, James D.
Make, Barry J.
Regan, Elizabeth A.
Walek, Dinesha S.
Daniel, Jerry J.
Kamatani, Yoichiro
Zelenika, Diana
Smith, Keith
McKean, David
Pedersen, Brent S.
Talbert, Janet
Kidd, Raven N.
Markin, Cheryl R.
Beckman, Kenneth B.
Lathrop, Mark
Schwarz, Marvin I.
Schwartz, David A.
NATURE GENETICS, 2013, 45 (06) : 613 - +
[24] Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
Wolpin, Brian M.
Rizzato, Cosmeri
Kraft, Peter
Kooperberg, Charles
Petersen, Gloria M.
Wang, Zhaoming
Arslan, Alan A.
Beane-Freeman, Laura
Bracci, Paige M.
Buring, Julie
Canzian, Federico
Duell, Eric J.
Gallinger, Steven
Giles, Graham G.
Goodman, Gary E.
Goodman, Phyllis J.
Jacobs, Eric J.
Kamineni, Aruna
Klein, Alison P.
Kolonel, Laurence N.
Kulke, Matthew H.
Li, Donghui
Malats, Nuria
Olson, Sara H.
Risch, Harvey A.
Sesso, Howard D.
Visvanathan, Kala
White, Emily
Zheng, Wei
Abnet, Christian C.
Albanes, Demetrius
Andreotti, Gabriella
Austin, Melissa A.
Barfield, Richard
Basso, Daniela
Berndt, Sonja I.
Boutron-Ruault, Marie-Christine
Brotzman, Michelle
Buechler, Markus W.
Bueno-de-Mesquita, H. Bas
Bugert, Peter
Burdette, Laurie
Campa, Daniele
Caporaso, Neil E.
Capurso, Gabriele
Chung, Charles
Cotterchio, Michelle
Costello, Eithne
Elena, Joanne
Funel, Niccola
NATURE GENETICS, 2014, 46 (09) : 994 - +
[25] Genome-wide association study in a Korean population identifies six novel susceptibility loci for rheumatoid arthritis
Kwon, Young-Chang
Lim, Jiwoo
Bang, So-Young
Ha, Eunji
Hwang, Mi Yeong
Yoon, Kyungheon
Choe, Jung-Yoon
Yoo, Dae-Hyun
Lee, Shin-Seok
Lee, Jisoo
Chung, Won Tae
Kim, Tae-Hwan
Sung, Yoon-Kyoung
Shim, Seung-Cheol
Choi, Chan-Bum
Jun, Jae-Bum
Kang, Young Mo
Shin, Jung-Min
Lee, Yeon-Kyung
Cho, Soo-Kyung
Kim, Bong-Jo
Lee, Hye-Soon
Kim, Kwangwoo
Bae, Sang-Cheol
ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 (11) : 1438 - 1445
[26] Genome-wide association study identifies five new schizophrenia loci
Ripke, Stephan
Sanders, Alan R.
Kendler, Kenneth S.
Levinson, Douglas F.
Sklar, Pamela
Holmans, Peter A.
Lin, Dan-Yu
Duan, Jubao
Ophoff, Roel A.
Andreassen, Ole A.
Scolnick, Edward
Cichon, Sven
Clair, David St.
Corvin, Aiden
Gurling, Hugh
Werge, Thomas
Rujescu, Dan
Blackwood, Douglas H. R.
Pato, Carlos N.
Malhotra, Anil K.
Purcell, Shaun
Dudbridge, Frank
Neale, Benjamin M.
Rossin, Lizzy
Visscher, Peter M.
Posthuma, Danielle
Ruderfer, Douglas M.
Fanous, Ayman
Stefansson, Hreinn
Steinberg, Stacy
Mowry, Bryan J.
Golimbet, Vera
De Hert, Marc
Jonsson, Erik G.
Bitter, Istvan
Pietilainen, Olli P. H.
Collier, David A.
Tosato, Sarah
Agartz, Ingrid
Albus, Margot
Alexander, Madeline
Amdur, Richard L.
Amin, Farooq
Bass, Nicholas
Bergen, Sarah E.
Black, Donald W.
Borglum, Anders D.
Brown, Matthew A.
Bruggeman, Richard
Buccola, Nancy G.
NATURE GENETICS, 2011, 43 (10) : 969 - 976
[27] Genome-wide association study identifies five loci associated with lung function
Repapi, Emmanouela
Sayers, Ian
Wain, Louise V.
Burton, Paul R.
Johnson, Toby
Obeidat, Ma'en
Zhao, Jing Hua
Ramasamy, Adaikalavan
Zhai, Guangju
Vitart, Veronique
Huffman, Jennifer E.
Igl, Wilmar
Albrecht, Eva
Deloukas, Panos
Henderson, John
Granell, Raquel
McArdle, Wendy L.
Rudnicka, Alicja R.
Barroso, Ines
Loos, Ruth J. F.
Wareham, Nicholas J.
Mustelin, Linda
Rantanen, Taina
Surakka, Ida
Imboden, Medea
Wichmann, H. Erich
Grkovic, Ivica
Jankovic, Stipan
Zgaga, Lina
Hartikainen, Anna-Liisa
Peltonen, Leena
Gyllensten, Ulf
Johansson, Asa
Zaboli, Ghazal
Campbell, Harry
Wild, Sarah H.
Wilson, James F.
Glaeser, Sven
Homuth, Georg
Voelzke, Henry
Mangino, Massimo
Soranzo, Nicole
Spector, Tim D.
Polasek, Ozren
Rudan, Igor
Wright, Alan F.
Heliovaara, Markku
Ripatti, Samuli
Pouta, Anneli
Naluai, Asa Torinsson
NATURE GENETICS, 2010, 42 (01) : 36 - U51
[28] Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci
Han, Mi-Ryung
Long, Jirong
Choi, Ji-Yeob
Low, Siew-Kee
Kweon, Sun-Seog
Zheng, Ying
Cai, Qiuyin
Shi, Jiajun
Guo, Xingyi
Matsuo, Keitaro
Iwasaki, Motoki
Shen, Chen-Yang
Kim, Mi Kyung
Wen, Wanqing
Li, Bingshan
Takahashi, Atsushi
Shin, Min-Ho
Xiang, Yong-Bing
Ito, Hidemi
Kasuga, Yoshio
Noh, Dong-Young
Matsuda, Koichi
Park, Min Ho
Gao, Yu-Tang
Iwata, Hiroji
Tsugane, Shoichiro
Park, Sue K.
Kubo, Michiaki
Shu, Xiao-Ou
Kang, Daehee
Zheng, Wei
HUMAN MOLECULAR GENETICS, 2016, 25 (15) : 3361 - 3371
[29] Genome-wide association study identifies new susceptibility loci for adolescent idiopathic scoliosis in Chinese girls
Zhu, Zezhang
Tang, Nelson Leung-Sang
Xu, Leilei
Qin, Xiaodong
Mao, Saihu
Song, Yueming
Liu, Limin
Li, Fangcai
Liu, Peng
Yi, Long
Chang, Jiang
Jiang, Long
Ng, Bobby Kin-Wah
Shi, Benlong
Zhang, Wen
Qiao, Jun
Sun, Xu
Qiu, Xusheng
Wang, Zhou
Wang, Fei
Xie, Dingding
Chen, Ling
Chen, Zhonghui
Jin, Mengran
Han, Xiao
Hu, Zongshan
Zhang, Zhen
Liu, Zhen
Zhu, Feng
Qian, Bang-ping
Yu, Yang
Wang, Bing
Lee, K. M.
Lee, Wayne Y. W.
Lam, T. P.
Qiu, Yong
Cheng, Jack Chun-Yiu
NATURE COMMUNICATIONS, 2015, 6
[30] A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia
Speedy, Helen E.
Di Bernardo, Maria Chiara
Sava, Georgina P.
Dyer, Martin J. S.
Holroyd, Amy
Wang, Yufei
Sunter, Nicola J.
Mansouri, Larry
Juliusson, Gunnar
Smedby, Karin E.
Roos, Groan
Jayne, Sandrine
Majid, Aneela
Dearden, Claire
Hall, Andrew G.
Mainou-Fowler, Tryfonia
Jackson, Graham H.
Summerfield, Geoffrey
Harris, Robert J.
Pettitt, Andrew R.
Allsup, David J.
Bailey, James R.
Pratt, Guy
Pepper, Chris
Fegan, Chris
Rosenquist, Richard
Catovsky, Daniel
Allan, James M.
Houlston, Richard S.
NATURE GENETICS, 2014, 46 (01) : 56 - +

← 1 2 3 4 5 →