A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population

被引：144

作者：

Shiraishi, Kouya ^{[1
]}

Kunitoh, Hideo ^{[2
]}

Daigo, Yataro ^{[3
,4
]}

Takahashi, Atsushi ^{[5
]}

Goto, Koichi ^{[6
]}

Sakamoto, Hiromi ^{[7
]}

Ohnami, Sumiko ^{[7
]}

Shimada, Yoko ^{[1
]}

Ashikawa, Kyota ^{[8
]}

Saito, Akira ^{[9
]}

Watanabe, Shun-ichi ^{[10
]}

Tsuta, Koji ^{[11
]}

Kamatani, Naoyuki ^{[5
]}

Yoshida, Teruhiko ^{[7
]}

Nakamura, Yusuke ^{[4
]}

Yokota, Jun ^{[12
]}

Kubo, Michiaki ^{[8
]}

Kohno, Takashi ^{[1
]}

机构：

[1] Natl Canc Ctr, Res Inst, Div Genome Biol, Tokyo 104, Japan

[2] Natl Canc Ctr, Div Thorac Oncol, Tokyo, Japan

[3] Shiga Univ Med Sci, Dept Med Oncol, Shiga, Japan

[4] Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome, Tokyo, Japan

[5] RIKEN, Ctr Genom Med, Lab Stat Anal, Kanagawa, Japan

[6] Natl Canc Ctr Hosp E, Thorac Oncol Div, Chiba, Japan

[7] Natl Canc Ctr, Res Inst, Div Genet, Tokyo 104, Japan

[8] RIKEN, Ctr Genom Med, Lab Genotyping Dev, Kanagawa, Japan

[9] StaGen Co Ltd, Stat Genet Anal Div, Tokyo, Japan

[10] Natl Canc Ctr, Div Thorac Surg, Tokyo, Japan

[11] Natl Canc Ctr, Div Pathol & Clin Labs, Tokyo, Japan

[12] Natl Canc Ctr, Res Inst, Div Multistep Carcinogenesis, Tokyo 104, Japan

来源：

NATURE GENETICS | 2012年 / 44卷 / 08期

基金：

日本学术振兴会;

关键词：

ULCERATIVE-COLITIS; NEVER SMOKERS; CANCER RISK; GENOTYPES; STRATIFICATION; VARIANTS; 5P15.33; IMPACT; SCAN; TP63;

D O I：

10.1038/ng.2353

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P-combined = 2.8 x 10(-40), odds ratio (OR) = 1.41) and 3q28 (rs10937405, P-combined = 6.9 x 10(-17), OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P-combined = 7.4 x 10(-11), OR = 1.20) and 6p21.3 (rs3817963, P-combined = 2.7 x 10(-10), OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.

引用

页码：900 / +

页数：5

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